Abstract | OBJECTIVE: DESIGN: Open transversal study. PATIENTS: Fifteen patients with active acromegaly and 15 controls were studied. MEASUREMENTS: RESULTS: Patients with acromegaly showed significantly higher levels of oxLDL (120 +/- 19 vs. 86 +/- 20 U/l, P < 0.001) and endothelin (P < 0.05), increased ceruloplasmin activity (P < 0.01) and a trend towards higher values in TBARS concentration (P = 0.07) in comparison to healthy controls. OxLDL was positively associated with GH, IGF-I and its binding protein 3 (r = 0.63, P < 0.001; r = 0.53, P < 0.01; and r = 0.56, P < 0.01; respectively). OxLDL showed direct associations with endothelin-1 (r = 0.53, P < 0.01) and ceruloplasmin activity (r = 0.43, P < 0.05). The other parameters evaluated were similar in both groups. CONCLUSIONS: The increase in plasma oxLDL levels, a direct marker of the plaque formation, could constitute a link between atherosclerosis and active acromegaly. LDL oxidation would not be the consequence of diminished antioxidant defences, but of an enhancement in prooxidant factors like ceruloplasmin.
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Authors | L Boero, L Cuniberti, N Magnani, M Manavela, V Yapur, M Bustos, L Gómez Rosso, T Meroño, L Marziali, L Viale, P Evelson, G Negri, F Brites |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 72
Issue 5
Pg. 654-60
(May 2010)
ISSN: 1365-2265 [Electronic] England |
PMID | 19681912
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Endothelin-1
- Insulin-Like Growth Factor Binding Protein 3
- Lipoproteins, LDL
- Thiobarbituric Acid Reactive Substances
- oxidized low density lipoprotein
- Human Growth Hormone
- Uric Acid
- Insulin-Like Growth Factor I
- Peroxidase
- Superoxide Dismutase
- Ceruloplasmin
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
- Bilirubin
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Topics |
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
(blood)
- Acromegaly
(blood, metabolism, pathology)
- Adult
- Aged
- Aged, 80 and over
- Bilirubin
(blood)
- Body Mass Index
- Ceruloplasmin
(analysis)
- Endothelin-1
(blood)
- Female
- Human Growth Hormone
(blood, metabolism)
- Humans
- Insulin-Like Growth Factor Binding Protein 3
(blood)
- Insulin-Like Growth Factor I
(analysis)
- Lipoproteins, LDL
(blood)
- Male
- Middle Aged
- Multivariate Analysis
- Peroxidase
(blood)
- Superoxide Dismutase
(blood)
- Thiobarbituric Acid Reactive Substances
(analysis)
- Uric Acid
(blood)
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