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Immunohistochemical expression of retinoblastoma and phospho-retinoblastoma protein in sheep lung exposed to fluoro-edenite fibers.

Abstract
The immunohistochemical expression of retinoblastoma protein (Rb) and its phosphorylated form (pRb) was investigated in an in vivo sheep model, i.e., lung tissue exposed to asbestos-like fibers. Rb is a phosphoprotein with a central role in controlling the cell cycle, cell growth regulation, differentiation, and apoptosis. pRb functions as a checkpoint in the G(1) phase, favoring cell growth, while the hypophosphorylated form (Rb) not only promotes cell-cycle arrest and a return to the G(1) phase, but also appears to be a key player in most instances of apoptosis. pRb overexpression was detected in alveolar epithelium and the interstitium, especially close to the fluoro-edenite fibers, whereas Rb immunostaining was faint or absent. The data suggest that the altered balance between pRb and Rb expression may be a programmed response to protect the organism against uncontrolled cell proliferation.
AuthorsGiuseppe Musumeci, Carla Loreto, Venera Cardile, Maria Luisa Carnazza, Giuseppina Martinez
JournalAnatomical science international (Anat Sci Int) Vol. 85 Issue 2 Pg. 74-8 (Jun 2010) ISSN: 1447-073X [Electronic] Japan
PMID19680741 (Publication Type: Journal Article)
Chemical References
  • Asbestos, Amphibole
  • Retinoblastoma Protein
  • fluor-edenite
Topics
  • Animals
  • Apoptosis (drug effects, genetics)
  • Asbestos, Amphibole (toxicity)
  • Asbestosis (etiology, metabolism, pathology)
  • Cell Differentiation (drug effects, genetics)
  • Cell Proliferation (drug effects)
  • Cell Transformation, Neoplastic (drug effects, metabolism)
  • Disease Models, Animal
  • Female
  • Immunohistochemistry
  • Lung Neoplasms (chemically induced, metabolism, pathology)
  • Phosphorylation (drug effects, physiology)
  • Respiratory Mucosa (drug effects, metabolism, pathology)
  • Retinoblastoma Protein (biosynthesis)
  • Sheep, Domestic

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