Abstract |
A 28-year-old man with adult-onset idiopathic male hypogonadotropic hypogonadism (MHH) is reported. He had been delivered normally and had normal puberty. He was referred to our hospital with a chief complaint of infertility. Serum levels of testosterone, luteinizing hormone, and follicle stimulating hormone (FSH) were low. Semen analysis demonstrated azoospermia. Pituitary hypofunction was suggested by gonadotropin releasing hormone ( GnRH) loading test. Magnetic resonance images did not detect any abnormalities in the hypothalamic-pituitary region. After a diagnosis of adult-onset hypogonadotropic hypogonadism was established, the patient received human chorionic gonadotropin (hCG) and recombinant FSH treatment. After 5 months, his sperm count reached 6.9 x 10(6) per ml and his wife became pregnant. Adult-onset HH in most cases is caused by tumors and trauma. To our knowledge 17 cases of adult-onset idiopathic HH have been reported, and there were only 3 cases that were caused by pituitary dysfunction. This report showed that r-FSH and hCG therapy was effective in promoting fertility in a patient with adult-onset idiopathic MHH.
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Authors | Hideyuki Terao, Takehiko Ogawa, Masahiro Yanagisawa, Miki Miyake, Futoshi Sano, Kaoru Kita, Takayuki Murakami, Kazuhide Makiyama, Noboru Nakaigawa, Hiroji Uemura, Masahiro Yao, Yoshinobu Kubota |
Journal | Hinyokika kiyo. Acta urologica Japonica
(Hinyokika Kiyo)
Vol. 55
Issue 7
Pg. 437-9
(Jul 2009)
ISSN: 0018-1994 [Print] Japan |
PMID | 19673435
(Publication Type: Case Reports, English Abstract, Journal Article, Review)
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Chemical References |
- Chorionic Gonadotropin
- Follicle Stimulating Hormone
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Topics |
- Adult
- Chorionic Gonadotropin
(administration & dosage)
- Female
- Follicle Stimulating Hormone
(administration & dosage)
- Humans
- Hypogonadism
(complications, diagnosis, drug therapy)
- Infertility, Male
(etiology)
- Male
- Pregnancy
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