Edaravone (MCI-186) is effective as a free radical scavenger following arteriovenous sheathotomy for treatment of macular oedema associated with branch retinal vein occlusion.

Abstract

AIMS:

To determine whether edaravone (MCI-186), a free radical scavenger, can reduce macular oedema and improve the visual acuity after arteriovenous sheathotomy in eyes with a branch retinal vein occlusion (BRVO).

METHODS:

Forty-seven eyes of 47 consecutive patients with a BRVO who were treated with arteriovenous sheathotomy were studied. The patients were assigned prospectively to either Group R who received 30 mg of edaravone (Radicut) systemically during the vitrectomy or Group N who did not receive any drugs. The postoperative visual acuity was measured before and 12 months after the operation.

RESULTS:

At 12 months postoperatively, the best-corrected visual acuity (BCVA) in logarithm of the minimum angle of resolution (logMAR) units improved significantly from 0.22 to 0.56 logMAR units in Group R and from 0.20 to 0.27 units in Group N (p = 0.016). Twenty-three of 27 cases (85%) in Group R and four of 15 cases (27%) in Group N showed an improvement in BCVA of >0.2 logMAR units (p = 0.0025).

CONCLUSION:

The better visual acuity in patients given edaravone than those without endaravone during the arteriovenous sheathotomy suggests that edaravone improved the physiology of the retinal cells after the arteriovenous sheathotomy.

• Authors: T Maeno, R Tano, H Takenaka, T Mano
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 93 Issue 11 Pg. 1479-82 (Nov 2009) ISSN: 1468-2079 [Electronic] England
• PMID: 19666924 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Free Radical Scavengers
• Edaravone
• Antipyrine

Topics

• Adult
• Aged
• Antipyrine (analogs & derivatives, therapeutic use)
• Edaravone
• Female
• Free Radical Scavengers (therapeutic use)
• Humans
• Macular Edema (drug therapy, etiology, surgery)
• Male
• Middle Aged
• Postoperative Care
• Retinal Vein Occlusion (complications, physiopathology)
• Vascular Surgical Procedures (methods)
• Visual Acuity (drug effects)
• Vitrectomy (methods)