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Oral administration of the thyrotropin-releasing hormone (TRH) analogue, taltireline hydrate, in spinal muscular atrophy.

Abstract
Spinal muscular atrophy is an entity of neurodegenerative disorders at the anterior horn neuron of the spinal cord caused by telomeric survival motor neuron gene abnormality. There is no definitive treatment for spinal muscular atrophy, but recent reports have indicated the efficacy of intravenous injection, but not oral administration, of thyrotropin-releasing hormone (TRH). We treated an 18-year-old male patient with spinal muscular atrophy type III by oral administration of the thyrotropin-releasing hormone analogue, taltireline hydrate. His muscle strength increased significantly after the therapy, and he showed no clinical or laboratory identifiable adverse effects, including thyroid-stimulating hormone suppression that had been observed with intravenous thyrotropin-releasing hormone therapy. Oral administration of this thyrotropin-releasing hormone analogue should be noted as a promising therapy for spinal muscular atrophy.
AuthorsZenichiro Kato, Miho Okuda, Yu Okumura, Takahiro Arai, Takahide Teramoto, Masaaki Nishimura, Hideo Kaneko, Naomi Kondo
JournalJournal of child neurology (J Child Neurol) Vol. 24 Issue 8 Pg. 1010-2 (Aug 2009) ISSN: 1708-8283 [Electronic] United States
PMID19666885 (Publication Type: Case Reports, Journal Article)
Chemical References
  • TA 0910
  • Thyrotropin-Releasing Hormone
Topics
  • Administration, Oral
  • Adolescent
  • Humans
  • Male
  • Muscle Strength (drug effects)
  • Spinal Muscular Atrophies of Childhood (drug therapy)
  • Thyrotropin-Releasing Hormone (administration & dosage, analogs & derivatives, therapeutic use)
  • Treatment Outcome

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