[Current concepts about the treatment of inflammatory bowel disease, biological therapy].

Abstract

BACKGROUND:

Crohn's disease and ulcerative colitis are chronic inflammatory disease of the intestine,which frequently require surgery for complications or failure of medical therapy.

OBJECTIVE:

We seek evidence and provide direction for clinicians about the optimal use of biologic therapy in order to enable steroid free remission in inflammatory bowel disease.

METHODS:

Scientific literature was reviewed using MEDLINE with a specific focus on biologic medical therapies for inducing and maintaining remission of Crohn disease and ulcerative colitis.

RESULTS:

Several therapies have demonstrated efficacy for the treatment of active, moderate-to-severe Crohn disease and ulcerative colitis. These include agents which induce remission [infliximab, certolizumaband adalimumab (CD only)] or maintain remission and spare corticosteroids [infliximab,certolizumab and adalimumab (CD only)]. In the patient with UC there is evidence about the efficacy of Infliximab for induce remission in moderate to-severe cases. We present additional information about new drugs in development for the treatment of both diseases.

CONCLUSION:

There are evidence about the efficacy and safety of biologic therapies that maximize remission and minimize corticosteroid dependence in patients with moderate-to-severe CD and UC.

• Authors: F J Bosques-Padilla, S L Galindo-Marines, J K Yamamoto-Farusho
• Journal: Revista de gastroenterologia de Mexico (Rev Gastroenterol Mex) Vol. 73 Issue 4 Pg. 217-30 ( 2008) ISSN: 0375-0906 [Print] Mexico
• Vernacular Title: Conceptos actuales acercadel tratamiento de la enfermedad inflamatoriaintestinal mediante terapia biológica.
• PMID: 19666271 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Cell Adhesion Molecules
• Steroids
• Interferons
• Curcumin

Topics

• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Biological Therapy (methods)
• Cell Adhesion Molecules (antagonists & inhibitors)
• Colitis, Ulcerative (therapy)
• Crohn Disease (therapy)
• Curcumin (therapeutic use)
• Humans
• Immunity, Innate (physiology)
• Inflammatory Bowel Diseases (therapy)
• Interferons (therapeutic use)
• Steroids (adverse effects, therapeutic use)