Systemic and local reactions of a water-soluble copolymer bone on a bony defect of rabbit model.

Abstract

BACKGROUND:

Ostene, a synthetic water-soluble bone hemostatic agent, is commercially available. In the current study, we evaluated the systemic and local effects of this copolymer in a rabbit model.

METHODS:

Eighteen rabbits underwent creation of a bony defect at right iliac crest. These rabbits were then evenly divided into 3 groups. In group 1, the defect surfaces were treated with bone wax; in group 2, the defect surfaces were treated with Ostene; in group 3, the defect surfaces were not treated with anything. Then, the animals underwent blood examinations, including WBC count, CRP, and ESR at 0, 1, 3, and 6 weeks, and were killed at 6 weeks for histologic examination. Another 6 rabbits (group 4) underwent the same surgical treatment of group 2 animals but had blood examinations of BUN and creatinine.

RESULTS:

The blood examinations showed that the WBC count, CRP, and ESR of all the animals in the first 3 groups were within normal limits in the postoperative periods. Microscopic examinations demonstrated residual bone wax and fibrotic tissue at the defect surfaces in group 1 animals. However, there was no Ostene at the defect surfaces in group 2 animals. The groups 2 and 3 animals showed no fibrotic tissue at the defect surfaces. The group 4 animals showed normal serum levels of BUN and creatinine in the postoperative periods.

CONCLUSION:

Ostene is absorbable and induces no systemic inflammation (including acute renal damage) and local inflammation in animal bodies.

• Authors: Tao-Chen Lee, Nyuk-Kong Chang, Feng-Wen Su, Yu-Lin Yang, Thung-Ming Su, Yu-Jun Lin, Wan-Ching Lin, Hsiu-Yu Huang
• Journal: Surgical neurology (Surg Neurol) Vol. 72 Suppl 2 Pg. S75-9; discussion S79 (Dec 2009) ISSN: 1879-3339 [Electronic] United States
• PMID: 19665194 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Bone Substitutes
• Drug Combinations
• Ostene
• Palmitates
• Polymers
• Waxes
• Poloxamer
• bone wax
• C-Reactive Protein

Topics

• Animals
• Biomarkers (analysis, metabolism)
• Bone Diseases (surgery)
• Bone Substitutes (chemistry, toxicity)
• C-Reactive Protein (analysis, metabolism)
• Disease Models, Animal
• Drug Combinations
• Inflammation (chemically induced, physiopathology)
• Kidney Diseases (chemically induced, physiopathology)
• Leukocyte Count
• Male
• Palmitates (therapeutic use)
• Poloxamer (chemistry, toxicity)
• Polymers (chemistry, toxicity)
• Rabbits
• Plastic Surgery Procedures (methods)
• Waxes (therapeutic use)