Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury-induced neuropathic pain in rats.
Abstract | BACKGROUND AND PURPOSE: Natural compounds obtained from marine organisms have received considerable attention as potential sources of novel drugs for treatment of human inflammatory diseases. Capnellene, isolated from the marine soft coral Capnella imbricate, 4,4,6a-trimethyl-3-methylene-decahydro-cyclopenta[]pentalene-2,3a-diol (GB9) exhibited anti-inflammatory actions on activated macrophages in vitro. Here we have assessed the anti-neuroinflammatory properties of GB9 and its acetylated derivative, acetic acid 3a-hydroxy-4,4,6a-trimethyl-3-methylene-decahydro-cyclopenta[]pentalen-2-yl ester (GB10). EXPERIMENTAL APPROACH: KEY RESULTS: In BV2 cells, GB9 and GB10 inhibited the expression of iNOS and COX-2, stimulated by IFN-gamma. Intrathecal administration of GB9 and GB10 inhibited CCI-induced nociceptive sensitization and thermal hyperalgesia in a dose-dependent manner. Intraperitoneal injection of GB9 inhibited CCI-induced thermal hyperalgesia and also inhibited CCI-induced activation of microglial cells and up-regulation of COX-2 in the dorsal horn of the lumbar spinal cord ipsilateral to the injury. CONCLUSION AND IMPLICATIONS: Taken together, these data indicate that the marine-derived capnellenes, GB9 and GB10, had anti-neuroinflammatory and anti-nociceptive properties in IFN-gamma-stimulated microglial cells and in neuropathic rats respectively. Therefore, capnellene may serve as a useful lead compound in the search for new therapeutic agents for treatment of neuroinflammatory diseases.
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Authors | Yen-Hsuan Jean, Wu-Fu Chen, Chun-Sung Sung, Chang-Yih Duh, Shi-Ying Huang, Chan-Shing Lin, Ming-Hon Tai, Shun-Fen Tzeng, Zhi-Hong Wen |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 158
Issue 3
Pg. 713-25
(Oct 2009)
ISSN: 1476-5381 [Electronic] England |
PMID | 19663884
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Anti-Inflammatory Agents, Non-Steroidal
- Cyclooxygenase 2 Inhibitors
- Sesquiterpenes
- delta9(12)-capnellene-8beta,10alpha-diol
- Interferon-gamma
- Nitric Oxide Synthase Type II
- Cyclooxygenase 2
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Topics |
- Analgesics
(pharmacology, therapeutic use)
- Animals
- Anthozoa
(chemistry)
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology, therapeutic use)
- Cell Line
- Constriction, Pathologic
(complications)
- Cyclooxygenase 2
(biosynthesis)
- Cyclooxygenase 2 Inhibitors
(pharmacology, therapeutic use)
- Hyperalgesia
(drug therapy)
- Interferon-gamma
(pharmacology)
- Lumbosacral Region
- Male
- Mice
- Microglia
(drug effects, enzymology)
- Neurons
(drug effects, enzymology)
- Nitric Oxide Synthase Type II
(antagonists & inhibitors, biosynthesis)
- Pain
(drug therapy, etiology, physiopathology)
- Peripheral Nervous System Diseases
(drug therapy, etiology, physiopathology)
- Rats
- Rats, Wistar
- Sesquiterpenes
(pharmacology, therapeutic use)
- Spinal Cord
(drug effects, enzymology)
- Up-Regulation
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