Type II estrogen binding sites (EBS) in intracranial tumors.

Abstract

Four meningiomas and six neuroepithelial tumors were assayed for the presence of estrogen receptors (ER), type II estrogen binding sites (EBS) and progesterone receptors (PgR). ER were detected in 7 out of 10 cases with levels ranging between 2.5 and 20.7 fmoles/mg of cytosolic protein. On the contrary, PgR were found in all samples (10 cases) and their levels ranged between 8.8 and 130.6 fmoles/mg of cytosolic protein. All tumor samples expressed appreciable amounts of type II EBS ranging between 452 and 2320 fmoles/mg of protein. Although the precise functional role of type II EBS is still unknown, their presence may reflect an hormonal sensitivity of these tumors.

• Authors: A Capelli, M Piantelli, A Rinelli, E Macri, R Ricci, L M Larocca, M Scerrati, R Roselli, M Iacoangeli, F O Ranelletti
• Journal: Journal of neurosurgical sciences (J Neurosurg Sci) 1990 Jul-Dec Vol. 34 Issue 3-4 Pg. 205-8 ISSN: 0390-5616 [Print] Italy
• PMID: 1965901 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, Estrogen
• Receptors, Progesterone

Topics

• Brain Neoplasms (chemistry)
• Female
• Humans
• Male
• Neoplasms, Nerve Tissue (chemistry)
• Receptors, Estrogen (analysis, classification)
• Receptors, Progesterone (analysis)