| Abstract | PURPOSE: To evaluate the efficacy and safety of trimethoprim/sulfamethoxazole and azithromycin combination for the treatment of ocular toxoplasmosis. METHODS: Nineteen ocular toxoplasmosis patients treated with trimethoprim/sulfamethoxazole and azithromycin +/- corticosteroid combination were retrospectively reviewed. Demographic data, clinical findings, the time interval until resolution of inflammation, recurrences, and drug side effects were collected. RESULTS: The mean follow-up time of the patients was 25.0 +/- 22.5 (range; 6 -66) months. Final visual acuity improved with a mean of 6 +/- 4 lines in 15 patients (78.9%). Inflammatory findings began to subside within 14.8 +/- 10.0 days. Three patients (15.8%) had recurrent attack. Only 1 patient (5.3%) had side effects from therapy. CONCLUSIONS: Trimethoprim/sulfamethoxazole and azithromycin combination is an effective and safe treatment modality for the treatment of ocular toxoplasmosis. |
| Authors | Alper Yazici, Pinar Cakar Ozdal, Ibrahim Taskintuna, Sevim Kavuncu, Gultekin Koklu
(Affiliation: Ulucanlar Eye Education and Research Hospital, Ankara, Turkey. lpryzc at gmail.com)
|
| Journal | Ocular immunology and inflammation
(Ocul Immunol Inflamm)
2009 Jul-Aug
Vol. 17
Issue 4
Pg. 289-91
ISSN: 1744-5078 [Electronic] England |
| PMID | 19657985
(Publication Type: Journal Article)
|
| Chemical References |
- Anti-Bacterial Agents
- Anti-Infective Agents
- Steroids
- Trimethoprim-Sulfamethoxazole Combination
- Azithromycin
|
| Topics |
- Adolescent
- Adult
- Anti-Bacterial Agents
(administration & dosage)
- Anti-Infective Agents
(administration & dosage)
- Azithromycin
(administration & dosage)
- Child
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Humans
- Macula Lutea
- Male
- Middle Aged
- Recurrence
- Steroids
(administration & dosage)
- Toxoplasmosis, Ocular
(drug therapy, physiopathology)
- Trimethoprim-Sulfamethoxazole Combination
(administration & dosage, adverse effects)
- Visual Acuity
(drug effects)
- Young Adult
|
