Anti-inflammatory activity of a polyphenolic enriched extract of Schima wallichii bark.

Abstract

In the present investigation, the anti-inflammatory activity of a polyphenolic enriched extract of Schima wallichii bark was evaluated in vitro using human peripheral blood mononuclear cells (PBMCs) and in vivo by carrageenan-induced paw oedema assay (acute study) and cotton pallet granuloma assay (chronic study). The extract exhibited significant inhibition of the production of tumour necrotic factor-α and interleukin-6 by PBMCs stimulated with lipopolysaccharide (LPS) in a concentration-dependent manner. The extract at the selected doses of 150 and 300 mg kg(-1) body weight p.o. exhibited significant dose-dependent anti-inflammatory responses, with 44.32 and 38.65% inhibition of inflammation in carrageenan-induced paw oedema and cotton pallet granuloma, respectively.

• Authors: Saikat Dewanjee, Vivekananda Mandal, Ranabir Sahu, Tarun K Dua, Ashis Manna, Subhash C Mandal
• Journal: Natural product research (Nat Prod Res) Vol. 25 Issue 7 Pg. 696-703 (Apr 2011) ISSN: 1478-6427 [Electronic] England
• PMID: 19657970 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Interleukin-6
• Lipopolysaccharides
• Plant Extracts
• Tumor Necrosis Factor-alpha
• Carrageenan

Topics

• Adult
• Animals
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Carrageenan (adverse effects)
• Edema (chemically induced, pathology, prevention & control)
• Granuloma (chemically induced, pathology, prevention & control)
• Humans
• Inflammation (chemically induced, drug therapy)
• Interleukin-6 (antagonists & inhibitors)
• Leukocytes, Mononuclear (immunology)
• Lipopolysaccharides (pharmacology)
• Plant Bark (chemistry)
• Plant Extracts (pharmacology, therapeutic use)
• Rats
• Rats, Wistar
• Theaceae (chemistry)
• Tumor Necrosis Factor-alpha (antagonists & inhibitors)
• Young Adult