Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells.

Abstract

Many natural components of plants extract are studied for their beneficial effects on health and particularly on carcinogenesis chemoprevention. In this study, we investigated the effect of citral (3,7-dimethyl-2,6-octadienal), a key component of essential oils extracted from several herbal plants, on the proliferation rate, cell cycle distribution, and apoptosis of the human breast cancer cell line MCF-7. The effects of this compound were also tested on cyclo-oxygenase activity. Citral treatment caused inhibition of MCF-7 cell growth (IC(50)-48 h: 18 x 10(-5)m), with a cycle arrest in G(2)/M phase and apoptosis induction. Moreover, we observed a decrease in prostaglandin E(2) synthesis 48 h after citral treatment. These findings suggest that citral has a potential chemopreventive effect.

• Authors: Wahid Chaouki, David Y Leger, Bertrand Liagre, Jean-Louis Beneytout, Mohamed Hmamouchi
• Journal: Fundamental & clinical pharmacology (Fundam Clin Pharmacol) Vol. 23 Issue 5 Pg. 549-56 (Oct 2009) ISSN: 1472-8206 [Electronic] England
• PMID: 19656204 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acyclic Monoterpenes
• Anticarcinogenic Agents
• Monoterpenes
• Cyclooxygenase 2
• Dinoprostone
• citral

Topics

• Acyclic Monoterpenes
• Anticarcinogenic Agents (pharmacology)
• Apoptosis (drug effects)
• Cell Culture Techniques
• Cell Cycle (drug effects)
• Cell Line, Tumor
• Cell Nucleus (drug effects, pathology)
• Cell Proliferation (drug effects)
• Cyclooxygenase 2 (biosynthesis)
• DNA Fragmentation (drug effects)
• Dinoprostone (biosynthesis)
• Dose-Response Relationship, Drug
• Humans
• Monoterpenes (pharmacology)
• Regression Analysis
• Time Factors