[Effect of reserpine on both CL seizures and cAMP levels in seizure mice brain].

Reserpine injection (1 mg/kg i.p.) could not only significantly reduce cAMP levels in both cerebral cortex and hippocampus in naive WC1 mice, but also potentiate the degree of seizures elicited by CL. Reserpine injection could significantly shorten CL-seizures latency and decrease its threshold, too. Reserpine pretreatment could also diminish CL seizure-induced accumulation of cAMP. These results indicated the cAMP level elevated by seizure activity was associated with monoamine neurotransmitter activity, and the seizure-induced accumulation of cAMP might take part in the process which eliminated the spread of seizure discharges and speeded up the termination of seizures.
AuthorsM Huang, Y Xie, Q Chen
JournalHua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao / [bian ji zhe, Hua xi yi ke da xue xue bao bian wei hui] (Hua Xi Yi Ke Da Xue Xue Bao) Vol. 21 Issue 3 Pg. 307-9 (Sep 1990) ISSN: 0257-7712 [Print] CHINA
PMID1965505 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Lactones
  • coriaria lactone
  • Reserpine
  • Cyclic AMP
  • Animals
  • Brain (metabolism)
  • Cyclic AMP (metabolism)
  • Epilepsy (chemically induced, metabolism)
  • Female
  • Lactones
  • Male
  • Mice
  • Mice, Inbred Strains
  • Reserpine (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: