Nidogen plays a role in the regenerative axon growth of adult sensory neurons through Schwann cells.

Abstract	We previously reported that nidogen is an extracellular matrix protein regulating Schwann cell proliferation and migration. Since Schwann cells play a critical role in peripheral nerve regeneration, nidogen may play a role in it via regulation of Schwann cells. Here, we demonstrate direct evidence that nidogen induces elongation of regenerative axon growth of adult sensory neurons, and that the effect is Schwann cell dependent. Continuous infusion of recombinant ectodomain of tumor endothelial marker 7, which specifically blocks nidogen function in Schwann cells, suppressed regenerative neurite growth in a sciatic nerve axotomy model. Taken together, it is likely that nidogen is required for proper regeneration of peripheral nerves after injury.
Authors	Hyun Kyoung Lee, In Ae Seo, Duk Joon Suh, Hwan Tae Park
Journal	Journal of Korean medical science (J Korean Med Sci) Vol. 24 Issue 4 Pg. 654-9 (Aug 2009) ISSN: 1598-6357 [Electronic] Korea (South)
PMID	19654948 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Membrane Glycoproteins Membrane Proteins Nerve Tissue Proteins Plxdc1 protein, rat Recombinant Proteins nidogen
Topics	Animals Axotomy Cell Movement Cell Proliferation Male Membrane Glycoproteins (physiology) Membrane Proteins (pharmacology) Nerve Regeneration Nerve Tissue Proteins (pharmacology) Neurites (drug effects, physiology, ultrastructure) Rats Rats, Sprague-Dawley Recombinant Proteins (pharmacology) Schwann Cells (cytology, physiology) Sensory Receptor Cells (physiology)

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