Epstein-Barr virus-associated smooth muscle tumor of the iris in a patient with transplant: a case report and review of the literature.

Abstract

Epstein-Barr virus infection has been linked to the development of smooth muscle tumors in immunocompromised patients with organ transplants and acquired immunodeficiency syndrome. A 52-year-old female recipient of a renal transplant presented with enlarging masses of the left iris. Incisional biopsy of the mass revealed a smooth muscle tumor of the iris. Epstein-Barr virus infection was confirmed by in situ hybridization for Epstein-Barr virus-encoded, small RNA in tumor cells. Eight months after total iridectomy the patient was free of disease. Although the prognosis and classification of Epstein-Barr virus-associated smooth muscle tumors are controversial, mortalities caused by these tumors are rare.

• Authors: Le Yu, Anthony J Aldave, Ben J Glasgow
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 133 Issue 8 Pg. 1238-41 (Aug 2009) ISSN: 1543-2165 [Electronic] United States
• PMID: 19653717 (Publication Type: Case Reports, Journal Article)

Chemical References

• RNA, Viral

Topics

• AIDS-Related Opportunistic Infections
• Acquired Immunodeficiency Syndrome (complications)
• Disease-Free Survival
• Epstein-Barr Virus Infections (pathology, virology)
• Female
• Herpesvirus 4, Human (isolation & purification)
• Humans
• Immunocompromised Host
• In Situ Hybridization
• Iris Neoplasms (pathology, surgery, virology)
• Kidney Transplantation
• Middle Aged
• Postoperative Complications
• RNA, Viral
• Smooth Muscle Tumor (pathology, surgery, virology)