Abstract | OBJECTIVES: DESIGN: Prospective placebo-controlled intervention study. SETTING: James J. Peters Veterans Affairs Medical Center. PARTICIPANTS: Patients (n=5) with tetraplegia and controls (n=7) participated. The groups were matched for age, height, and weight; the average duration of injury in the tetraplegia group was 22+/-14 years. INTERVENTION: Subjects with tetraplegia visited the laboratory twice, receiving placebo on day 1 and L-NAME (1.0 mg/kg) on day 2. The agents were infused via an intravenous catheter over 60 minutes with the patient in the supine position. Data were collected during the infusion and then during head-up tilt to 45 degrees for 30 minutes. Control subjects visited the laboratory once for placebo infusion and the head-up tilt maneuver. MAIN OUTCOME MEASURE: Orthostatic MAP. RESULTS: Orthostatic MAP was reduced after placebo infusion in subjects with tetraplegia compared with controls (69+/-11 vs 89+/-9 mmHg, respectively; P<.01) and compared with L-NAME infusion (90+/-16 mmHg; P<.01). Orthostatic MAP did not differ when comparing the tetraplegia group with controls after L-NAME infusion. Orthostatic aldosterone levels were increased after placebo compared with L-NAME infusion in persons with tetraplegia; plasma renin levels did not differ among the groups. CONCLUSIONS:
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Authors | Jill M Wecht, Miroslav Radulovic, Michael F Lafountaine, Dwindally Rosado-Rivera, Run-Lin Zhang, William A Bauman |
Journal | Archives of physical medicine and rehabilitation
(Arch Phys Med Rehabil)
Vol. 90
Issue 8
Pg. 1428-34
(Aug 2009)
ISSN: 1532-821X [Electronic] United States |
PMID | 19651280
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Placebos
- Nitric Oxide Synthase
- NG-Nitroarginine Methyl Ester
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Topics |
- Adult
- Analysis of Variance
- Blood Pressure
(drug effects)
- Case-Control Studies
- Female
- Heart Rate
(drug effects)
- Humans
- Hypotension, Orthostatic
(drug therapy)
- Male
- Middle Aged
- NG-Nitroarginine Methyl Ester
(pharmacology)
- Nitric Oxide Synthase
(antagonists & inhibitors)
- Placebos
- Prospective Studies
- Quadriplegia
(enzymology)
- Spinal Cord Injuries
(drug therapy)
- Tilt-Table Test
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