Abstract | PURPOSE: To study the natural course of changes observed in the retinal pigment epithelium (RPE) on spectral domain OCT transverse and RPE fit C-scans corresponding to the leakage point observed on fundus fluorescein angiograms in central serous chorioretinopathy (CSC). METHODS: Thirteen patients with acute CSC were prospectively enrolled and followed up for 6 months. All were examined using Zeiss Cirrus HD-OCT Model 4000. Transverse and RPE fit C-scans corresponding to point of leakage were superimposed on an OCT fundus photograph and correlated with the leakage point on a fluorescein angiogram. The RPE alterations observed at the leakage point were noted at presentation and follow-up. RESULTS: Transverse and RPE fit C-scans showed an irregularity of RPE resembling a 'honeycomb' pattern in 11 (85%) eyes at the point corresponding to the fluorescein leakage site. These were observed as pigment epithelium detachment (PED) on Raster line scan. Six of these 11 eyes (54.5%) showed a disruption/breach in the RPE on transverse C-scan and on RPE fit C-scan. All eyes showed a resolution of subretinal fluid with a closure of microrip, and the honeycombed pattern at the leakage site was replaced with RPE hypertrophy. CONCLUSION: RPE microrips show spontaneous closure in the natural course of CSC.
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Authors | V Gupta, P Gupta, M R Dogra, A Gupta |
Journal | Eye (London, England)
(Eye (Lond))
Vol. 24
Issue 4
Pg. 595-9
(Apr 2010)
ISSN: 1476-5454 [Electronic] England |
PMID | 19648895
(Publication Type: Journal Article)
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Topics |
- Adult
- Central Serous Chorioretinopathy
(complications, pathology)
- Female
- Fundus Oculi
- Humans
- Male
- Middle Aged
- Prospective Studies
- Remission, Spontaneous
- Retinal Detachment
(etiology, pathology)
- Retinal Pigment Epithelium
(pathology)
- Tomography, Optical Coherence
(methods)
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