Spontaneous closure of retinal pigment epithelium microrip in the natural course of central serous chorioretinopathy.

Abstract

PURPOSE:

To study the natural course of changes observed in the retinal pigment epithelium (RPE) on spectral domain OCT transverse and RPE fit C-scans corresponding to the leakage point observed on fundus fluorescein angiograms in central serous chorioretinopathy (CSC).

METHODS:

Thirteen patients with acute CSC were prospectively enrolled and followed up for 6 months. All were examined using Zeiss Cirrus HD-OCT Model 4000. Transverse and RPE fit C-scans corresponding to point of leakage were superimposed on an OCT fundus photograph and correlated with the leakage point on a fluorescein angiogram. The RPE alterations observed at the leakage point were noted at presentation and follow-up.

RESULTS:

Transverse and RPE fit C-scans showed an irregularity of RPE resembling a 'honeycomb' pattern in 11 (85%) eyes at the point corresponding to the fluorescein leakage site. These were observed as pigment epithelium detachment (PED) on Raster line scan. Six of these 11 eyes (54.5%) showed a disruption/breach in the RPE on transverse C-scan and on RPE fit C-scan. All eyes showed a resolution of subretinal fluid with a closure of microrip, and the honeycombed pattern at the leakage site was replaced with RPE hypertrophy.

CONCLUSION:

RPE microrips show spontaneous closure in the natural course of CSC.

• Authors: V Gupta, P Gupta, M R Dogra, A Gupta
• Journal: Eye (London, England) (Eye (Lond)) Vol. 24 Issue 4 Pg. 595-9 (Apr 2010) ISSN: 1476-5454 [Electronic] England
• PMID: 19648895 (Publication Type: Journal Article)

Topics

• Adult
• Central Serous Chorioretinopathy (complications, pathology)
• Female
• Fundus Oculi
• Humans
• Male
• Middle Aged
• Prospective Studies
• Remission, Spontaneous
• Retinal Detachment (etiology, pathology)
• Retinal Pigment Epithelium (pathology)
• Tomography, Optical Coherence (methods)