Primary myelodysplastic syndrome in Jordan: a single-centre experience.

Abstract

OBJECTIVE:

Study of the disease patterns and clinical evaluation of myelodysplastic syndrome (MDS).

SUBJECTS AND METHODS:

A retrospective analysis was carried out on 85 patients, with MDS who were followed up over a period of 23 years at Jordan University Hospital, Amman, Jordan. Cases were analyzed according to the French, American and British Classification.

RESULTS:

Of the 85 patients, 42 (49.4%) were females and 43 (50%) males; mean age was 59 +/- 19 years (range 18-88). Most subtypes found in patients were refractory anemia (RA) in 27 (31.8%) and RA with excess blasts (RAEB) in 28 (32.9%). Adverse prognostic indicators were RAEB subtype and requirement for blood transfusion.

CONCLUSION:

Our findings showed that MDSs appeared at a younger age and tended to be of the aggressive subtype. Chronic myelomonocytic leukemia subtype seemed to appear dominantly in men.

• Authors: Abdalla Awidi, Ahmad Magableh, Ziad Taimeh, Hashim Ayyad, Nazzal Bsoul, Musleh Tarawneh
• Journal: Medical principles and practice : international journal of the Kuwait University, Health Science Centre (Med Princ Pract) Vol. 18 Issue 5 Pg. 351-5 ( 2009) ISSN: 1423-0151 [Electronic] Switzerland
• PMID: 19648755 (Publication Type: Journal Article)
• Copyright: Copyright 2009 S. Karger AG, Basel.

Topics

• Adolescent
• Adult
• Age Distribution
• Aged
• Aged, 80 and over
• Anemia, Refractory, with Excess of Blasts (epidemiology, physiopathology)
• Anemia, Sideroblastic (epidemiology, physiopathology)
• Developing Countries
• Disease Progression
• Female
• Hospitals, University
• Humans
• Jordan (epidemiology)
• Kaplan-Meier Estimate
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (epidemiology, physiopathology)
• Male
• Middle Aged
• Retrospective Studies
• Sex Distribution
• Young Adult