Poly(gamma-glutamic acid) nano-particles combined with mucosal influenza virus hemagglutinin vaccine protects against influenza virus infection in mice.

Abstract	Adding poly(gamma-glutamic acid) nano-particles (gamma-PGA-NPs), a safe, natural material, to subcutaneous immunization with influenza virus hemagglutinin (HA) vaccine increases the protective immune responses against influenza virus in mice. Here, we examined whether intranasal administration of the HA vaccine with gamma-PGA-NPs would induce protection from influenza virus challenge in mice. Intranasal immunization with the mixture of gamma-PGA-NPs and HA vaccine from an influenza virus strain A/PR/8/34 (H1N1) or A/New Caledonia/20/99 (H1N1) enhanced protection of mice from A/PR/8/34 infection. Intranasal immunization with A/New Caledonia/20/99 HA vaccine and gamma-PGA-NPs induced cell-mediated immune responses and neutralizing antibody production for both A/New Caledonia/20/99 and A/PR/8/34. These data suggest that gamma-PGA-NPs may have potential for clinical applications as a mucosal adjuvant.
Authors	Shigefumi Okamoto, Masaaki Matsuura, Takami Akagi, Mitsuru Akashi, Takeshi Tanimoto, Toyokazu Ishikawa, Michiaki Takahashi, Koichi Yamanishi, Yasuko Mori
Journal	Vaccine (Vaccine) Vol. 27 Issue 42 Pg. 5896-905 (Sep 25 2009) ISSN: 1873-2518 [Electronic] Netherlands
PMID	19647814 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Adjuvants, Immunologic Antibodies, Viral Cytokines Hemagglutinin Glycoproteins, Influenza Virus Influenza Vaccines poly(gamma-glutamic acid) Polyglutamic Acid
Topics	Adjuvants, Immunologic (pharmacology) Administration, Intranasal Animals Antibodies, Viral (immunology) Cell Proliferation Cytokines (immunology) Female Hemagglutinin Glycoproteins, Influenza Virus (immunology) Immunity, Cellular Influenza A Virus, H1N1 Subtype (immunology) Influenza Vaccines (administration & dosage, immunology) Mice Mice, Inbred BALB C Nanoparticles Neutralization Tests Orthomyxoviridae Infections (prevention & control) Polyglutamic Acid (analogs & derivatives, immunology) Spleen (cytology, immunology)

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