Sentinel lymph node accumulation of Lymphoseek and Tc-99m-sulfur colloid using a "2-day" protocol.

Lymphoseek is a receptor-binding radiopharmaceutical specifically designed for sentinel lymph node (SLN) mapping. We conducted a clinical trial which measured the injection site clearance and sentinel lymph node accumulation after a single intradermal injection of Lymphoseek or unfiltered [(99m)Tc]sulfur colloid (TcSC) using a "2-day" protocol for SLN mapping of breast cancer. Eleven patients with breast cancer participated in this study. Five patients received an intradermal administration of 1.0 nmol of (99m)Tc-labeled Lymphoseek; SLN mapping was performed on four subjects within 19 to 27 h. Six subjects received an intradermal administration of TcSC; SLN mapping was performed on five subjects within 18 to 26 h. Lymphoseek exhibited a significantly (P<.001) faster injection site clearance than TcSC. The mean Lymphoseek clearance half-time was 2.18+/-1.09 h compared to 57.4+/-92.8 h for TcSC. The mean sentinel lymph node uptake of Lymphoseek (1.5+/-1.7%) and TcSC (3.5+/-3.1%) was statistically equivalent (P=.213). When an intradermal injection is employed, Lymphoseek demonstrated faster injection site clearance than unfiltered [(99m)Tc]sulfur colloid and persistent SLN accumulation for at least 24 h.
AuthorsAnne M Wallace, Carl K Hoh, Karl K Limmer, Denise D Darrah, Gery Schulteis, David R Vera
JournalNuclear medicine and biology (Nucl Med Biol) Vol. 36 Issue 6 Pg. 687-92 (Aug 2009) ISSN: 1872-9614 [Electronic] England
PMID19647175 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Mannans
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • technetium-diethylenetriaminepentaacetic acid-mannosyl-dextran
  • Technetium Tc 99m Sulfur Colloid
  • Pentetic Acid
  • Dextrans
  • Technetium Tc 99m Pentetate
  • Aged
  • Breast Neoplasms (metabolism, pathology)
  • Dextrans (administration & dosage, pharmacokinetics)
  • Female
  • Humans
  • Injections, Intradermal
  • Lymph Nodes (metabolism)
  • Mannans (administration & dosage, pharmacokinetics)
  • Middle Aged
  • Organotechnetium Compounds (administration & dosage, pharmacokinetics)
  • Pentetic Acid (administration & dosage, pharmacokinetics)
  • Radioactivity
  • Radiopharmaceuticals (administration & dosage, pharmacokinetics)
  • Sentinel Lymph Node Biopsy
  • Technetium Tc 99m Pentetate (analogs & derivatives)
  • Technetium Tc 99m Sulfur Colloid (administration & dosage, pharmacokinetics)
  • Time Factors

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