Abstract | INTRODUCTION: PATIENTS AND METHODS: Thirty-eight patients were treated between 1971 and 2005 at the University Medical Center Groningen (UMCG). Thirty patients presented with primary disease (79%) and 8 patients with locally recurrent disease (21%). The treatment consisted of surgical resection and in case of marginal or positive resection margins (R1 resection) adjuvant radiotherapy. RESULTS: Adequate surgical margins as a single modality was associated with 100% local control in all primary DFSPs. Two patients whose resection specimens had microscopically positive resection margins had withdrawn from adjuvant radiotherapy and developed local recurrence (LF rate 7%). Two of the 8 patients referred with a local recurrence developed a second recurrence (LF rate 25%); one of these patients developed distant disease and ultimately died of systemic disease. None of the five patients with DFSP-FS developed LF after treatment at the UMCG. After a median follow-up of 89 (12-271) months, the 10-year disease-free survival was 85% and the 10-year disease specific survival was 100%. CONCLUSION: After wide surgical resection of a DFSP or DFSP-FS, or an R1 resection combined with adjuvant radiotherapy the risk of local recurrence is extremely low.
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Authors | S Ten Heuvel, A Suurmeijer, E Pras, R J Van Ginkel, H J Hoekstra |
Journal | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
(Eur J Surg Oncol)
Vol. 36
Issue 1
Pg. 89-94
(Jan 2010)
ISSN: 1532-2157 [Electronic] England |
PMID | 19646839
(Publication Type: Journal Article)
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Copyright | Copyright (c) 2009 Elsevier Ltd. All rights reserved. |
Topics |
- Adult
- Child
- Dermatofibrosarcoma
(radiotherapy, surgery)
- Disease-Free Survival
- Female
- Humans
- Male
- Middle Aged
- Mohs Surgery
- Neoplasm Recurrence, Local
(surgery)
- Radiotherapy, Adjuvant
- Skin Neoplasms
(radiotherapy, surgery)
- Young Adult
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