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Dermatofibrosarcoma protuberans: recurrence is related to the adequacy of surgical margins.

AbstractINTRODUCTION:
The aim of the study was to investigate the results of surgical treatment in primary and recurrent dermatofibrosarcoma protuberans (DFSP), with respect to local tumor control.
PATIENTS AND METHODS:
Thirty-eight patients were treated between 1971 and 2005 at the University Medical Center Groningen (UMCG). Thirty patients presented with primary disease (79%) and 8 patients with locally recurrent disease (21%). The treatment consisted of surgical resection and in case of marginal or positive resection margins (R1 resection) adjuvant radiotherapy.
RESULTS:
Adequate surgical margins as a single modality was associated with 100% local control in all primary DFSPs. Two patients whose resection specimens had microscopically positive resection margins had withdrawn from adjuvant radiotherapy and developed local recurrence (LF rate 7%). Two of the 8 patients referred with a local recurrence developed a second recurrence (LF rate 25%); one of these patients developed distant disease and ultimately died of systemic disease. None of the five patients with DFSP-FS developed LF after treatment at the UMCG. After a median follow-up of 89 (12-271) months, the 10-year disease-free survival was 85% and the 10-year disease specific survival was 100%.
CONCLUSION:
After wide surgical resection of a DFSP or DFSP-FS, or an R1 resection combined with adjuvant radiotherapy the risk of local recurrence is extremely low.
AuthorsS Ten Heuvel, A Suurmeijer, E Pras, R J Van Ginkel, H J Hoekstra
JournalEuropean journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (Eur J Surg Oncol) Vol. 36 Issue 1 Pg. 89-94 (Jan 2010) ISSN: 1532-2157 [Electronic] England
PMID19646839 (Publication Type: Journal Article)
CopyrightCopyright (c) 2009 Elsevier Ltd. All rights reserved.
Topics
  • Adult
  • Child
  • Dermatofibrosarcoma (radiotherapy, surgery)
  • Disease-Free Survival
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mohs Surgery
  • Neoplasm Recurrence, Local (surgery)
  • Radiotherapy, Adjuvant
  • Skin Neoplasms (radiotherapy, surgery)
  • Young Adult

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