Developmental toxicity potential of grayanotoxin I in mice and chicks.

Abstract

Developmental toxicity potential of grayanotoxin I (GTX I), a toxic diterpenoid contained in plants of the family Ericaceae, with sodium ionophore activity, was studied in mice and chicks. In mice, intraperitoneal injections of 1.5 mg GTX I/kg body weight of mouse for three consecutive days during the organogenetic period caused some dams to die, but neither embryotoxicity nor teratogenicity was detected. In chicks, a single injection of 0.1-1.0 microgram GTX I per egg into the extraembryonic coelom on day 1.5 or 2 of incubation, or into the amnionic cavity on day 3 or 4 of incubation induced neither embryotoxic nor teratogenic signs, but 10 micrograms GTX I per egg showed lethal effects when applied on each of those days.

• Authors: T Kobayashi, M Yasuda, I Seyama
• Journal: The Journal of toxicological sciences (J Toxicol Sci) Vol. 15 Issue 4 Pg. 227-34 (Nov 1990) ISSN: 0388-1350 [Print] Japan
• PMID: 1964479 (Publication Type: Journal Article)

Chemical References

• Diterpenes
• Sodium Channels
• Teratogens
• grayanotoxin I

Topics

• Animals
• Chick Embryo
• Diterpenes (toxicity)
• Female
• Maternal-Fetal Exchange
• Mice
• Mice, Inbred ICR
• Pregnancy
• Sodium Channels (drug effects)
• Teratogens