Abstract | BACKGROUND AND PURPOSE: METHODS: Serum samples were collected at 4 annual intervals in 52 stroke-free participants from the Northern Manhattan Study ( NOMAS) and assayed for hsCRP and Lp-PLA2 mass and activity levels using standard techniques. Log transformation of levels was performed as needed to stabilize the variance. Stability of marker levels over time was assessed using random effects models unadjusted and adjusted for demographics and other risk factors. In addition, samples from 37 initially stroke-free participants with stroke (n=17) or MI (n=20) were available for measurement before and after the vascular event (median 5 days, range 2 to 40 days). Levels before and after events were compared using nonparametric tests. RESULTS:
HsCRP and Lp-PLA2 activity levels were stable over time, whereas Lp-PLA2 mass levels decreased on average 5% per year (P=0.0015). Using accepted thresholds to define risk categories of Lp-PLA2 mass, there was no significant change over time. HsCRP increased after stroke (from median 2.2 mg/L prestroke to 6.5 mg/L poststroke; P=0.0067) and MI (from median 2.5 mg/L pre-MI to 13.5 mg/L post-MI; P<0.0001). Lp-PLA2 mass and activity levels both decreased significantly after stroke and MI (for Lp-PLA2 mass, from median 210.0 ng/mL to 169.4 ng/mL poststroke, P=0.0348, and from median 233.0 ng/mL to 153.9 post-MI, P<0.0001). CONCLUSION:
Lp-PLA2 mass levels decrease modestly, whereas hsCRP and Lp-PLA2 activity appear stable over time. Acutely after stroke and MI, hsCRP increases whereas Lp-PLA2 mass and activity levels decrease. These changes imply that measurements made soon after stroke and MI are not reflective of prestroke levels and may be less reliable for long-term risk stratification.
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Authors | Mitchell S V Elkind, Vladimir Leon, Yeseon P Moon, Myunghee C Paik, Ralph L Sacco |
Journal | Stroke
(Stroke)
Vol. 40
Issue 10
Pg. 3233-7
(Oct 2009)
ISSN: 1524-4628 [Electronic] United States |
PMID | 19644070
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- C-Reactive Protein
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
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Topics |
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
(analysis, blood)
- Aged
- Aged, 80 and over
- Biomarkers
(analysis, blood)
- C-Reactive Protein
(analysis, metabolism)
- Down-Regulation
(physiology)
- Female
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(blood, diagnosis, physiopathology)
- Predictive Value of Tests
- Risk Factors
- Stroke
(blood, diagnosis, physiopathology)
- Time Factors
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