A case-control study comparing percutaneous radiofrequency ablation alone or combined with transcatheter arterial chemoembolization for hepatocellular carcinoma.

Abstract

AIMS:

To assess whether combining percutaneous radiofrequency ablation (PRFA) with transcatheter arterial chemoembolization (TACE) was better than PRFA alone for hepatocellular carcinoma (HCC).

MATERIALS AND METHODS:

One hundered twenty patients (with a solitary HCC<or=7.0 cm in diameter or multiple HCC (<or=3), each <or=3.0 cm in diameter) treated with PRFA combined with TACE were compared with 120 well-matched controls selected from a pool of 652 patients who received PRFA alone during the study period.

RESULTS:

The 1-, 2-, 3-, 5-year overall survival rates for the TACE-PRFA and PRFA groups were 93%, 83%, 75%, 50%, and 89%, 76%, 64%, 42%, respectively (p=.045). Subgroup analyses showed the survival for the TACE-PRFA group was better than the PRFA group for tumors >5.0 cm (p=.031) and for multiple tumors (p=.032), but not for tumors <or=5.0 cm (p=.319) and for solitary tumor (p=.128). The 1-, 2-, 3-, 5-year progression free survival (PFS) for the TACE-PRFA and PRFA groups was 90%, 76%, 63%, 42%, and 76%, 60%, 47%, 30%, respectively (p=.002). Child-pugh class, Diameter of tumor and hepatitis B surface antigen (HBsAg) were significant prognostic factors.

CONCLUSION:

Patients treated with TACE-PRFA had better overall survivals than PRFA alone, but only in a subgroup of patients with tumor >5 cm or multiple tumors.

• Authors: Z-W Peng, M-S Chen, H-H Liang, H-J Gao, Y-J Zhang, J-Q Li, Y-Q Zhang, W Y Lau
• Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (Eur J Surg Oncol) Vol. 36 Issue 3 Pg. 257-63 (Mar 2010) ISSN: 1532-2157 [Electronic] England
• PMID: 19643561 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright (c) 2009 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents

Topics

• Antineoplastic Agents (administration & dosage)
• Carcinoma, Hepatocellular (mortality, pathology, therapy)
• Catheter Ablation (methods)
• Catheterization
• Chemoembolization, Therapeutic (methods)
• China (epidemiology)
• Female
• Follow-Up Studies
• Humans
• Injections, Intra-Arterial
• Liver Neoplasms (mortality, pathology, therapy)
• Male
• Middle Aged
• Neoplasm Staging
• Retrospective Studies
• Survival Rate (trends)
• Treatment Outcome