Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes.

Abstract	Apomorphine (Apo), a D1/D2 Dopamine (DA) agonist, at high doses (500 micrograms/kg) induces a short-lasting insomnia, antagonized by a secondary injection of corticotropin-like intermediate lobe peptide (CLIP, 10 ng); these effects are also observed with hypophysectomized (hypoX) rats. The administration of the serotonin (5-HT) agonist 8-hydroxy-2-di-n-propylamino-tetralin (8-OHDPAT, 0.3 mg/kg) induces also an insomnia which, unlike Apo, is followed by a significant PS rebound. CLIP, again, antagonizes the 8-OHDPAT-induced insomnia. Finally, Bromocriptine (5 mg/kg), an agonist for both DA and 5-HT, induces first an insomnia (antagonized by CLIP), followed by a PS rebound; these effects persist in hypoX rats.
Authors	N Chastrette, R Cespuglio, Y L Lin, M Jouvet
Journal	Neuropeptides (Neuropeptides) Vol. 15 Issue 2 Pg. 75-88 (Feb 1990) ISSN: 0143-4179 [Print] Netherlands
PMID	1964203 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Dopamine Antagonists Peptide Fragments Receptors, Dopamine Tetrahydronaphthalenes Serotonin Bromocriptine Corticotropin-Like Intermediate Lobe Peptide alpha-MSH Pro-Opiomelanocortin 8-Hydroxy-2-(di-n-propylamino)tetralin Adrenocorticotropic Hormone Apomorphine Dopamine
Topics	8-Hydroxy-2-(di-n-propylamino)tetralin Adrenocorticotropic Hormone (pharmacology) Animals Apomorphine (antagonists & inhibitors, pharmacology, toxicity) Bromocriptine (pharmacology) Corticotropin-Like Intermediate Lobe Peptide Dopamine (physiology) Dopamine Antagonists Hypoxia (physiopathology) Male Peptide Fragments (pharmacology) Pro-Opiomelanocortin (pharmacology) Rats Receptors, Dopamine (drug effects, physiology) Serotonin (physiology) Sleep (drug effects) Sleep Initiation and Maintenance Disorders (chemically induced) Sleep Stages (drug effects) Tetrahydronaphthalenes (pharmacology) alpha-MSH (analogs & derivatives, pharmacology)

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