| Abstract | Renal alterations in hypothyroidism include decreased glomerular filtration rate and renal plasma flow. We herein report a case of amiodarone -induced hypothyroidism associated with a rapid decrease of renal function, reversible upon amiodarone withdrawal. A 72-year-old man presented to our clinic in August 2007 reporting a recent deterioration of renal function. Ten weeks before he was admitted to another hospital for a supraventricular tachyarrhythmia treated with carvedilol 12.5 mg/day and amiodarone 400 mg/day. On admission, laboratory tests revealed altered renal function (serum creatinine 6 mg/dl, blood urea nitrogen 78 mg/dl) and severe hypothyroidism (free T4 0.27 pg/ml, free T3 1.49 pg/ml, TSH 183.36 mU/l). Amiodarone and carvedilol were stopped, while levothyroxine 75 mcg/die was started. After three months renal function had completely recovered to 1.9 mg/dl, BUN 28 mg/dl, with concurrent improvement of thyroid function free T4 14.2 pg/ml, free T3 6.4 pg/ml, TSH 15.5 mU/l. |
| Authors | R Luciani, C Falcone, F Principe, G Punzo, P Menè
(Affiliation: Department of Nephrology, Sant'Andrea University Hospital, University of Rome "La Sapienza", Rome, Italy. rluciani at ospedalesantandrea.it)
|
| Journal | Clinical nephrology
(Clin Nephrol)
Vol. 72
Issue 1
Pg. 79-80
(Jul 2009)
ISSN: 0301-0430 [Print] Germany |
| PMID | 19640392
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Anti-Arrhythmia Agents
- Amiodarone
|
| Topics |
- Aged
- Amiodarone
(adverse effects)
- Anti-Arrhythmia Agents
(adverse effects)
- Humans
- Hypothyroidism
(chemically induced, complications)
- Kidney Failure, Acute
(etiology)
- Kidney Function Tests
- Male
- Tachycardia, Supraventricular
(drug therapy)
|
