[Studies on chemical constituents in fruit of Alpinia oxyphylla].

Abstract

OBJECTIVE:

To study the chemical constituents in fruit of Alpinia oxyphylla and their cytotoxicities on cancer cell lines.

METHOD:

Compounds were isolated and purified by various column chromatographic methods. Their structures were determined by physico-chemical properties and spectral analyses. Compound cytotoxicity was assessed by the sulforhodamine B (SRB) assay.

RESULT:

Eight compounds were obtained from Me2CO-H2O (70%) extract of the fruit of A. oxyphylla and their structures were identified as: (9E)-humulene-2, 3; 6, 7-diepoxide (1), 3(12), 7(13), 9(E)-humulatriene-2, 6-diol (2), (-)-oplopanone (3), yakuchinone A (4), yakuchinone B (5), tectochrysin (6), isovanillin (7), (2E, 4E)-6-hydroxy-2, 6-dimethylhepta-2, 4-dienal (8), and the cytotoxicities of compounds 1, 3-5 on cancer cell lines, A549, HT-29 and SGC-7901, were also investigated.

CONCLUSION:

Compounds 1-3, 7, 8 were isolated for the first time from this genus and compounds 1, 3-5 exhibited no cytotoxicity against three cancer cell lines at a concentration of 10 mg x L(-1).

• Authors: Junju Xu, Ninghua Tan, Guangzhi Zeng, Hongjin Han, Huoqiang Huang, Changjiu Ji, Meiju Zhu, Yumei Zhang
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 34 Issue 8 Pg. 990-3 (Apr 2009) ISSN: 1001-5302 [Print] China
• PMID: 19639783 (Publication Type: Journal Article)

Chemical References

• Benzaldehydes
• Diarylheptanoids
• Drugs, Chinese Herbal
• Flavonoids
• yakuchinone B
• isovanillin
• Guaiacol
• yakuchinone-A
• tectochrysin

Topics

• Alpinia (chemistry)
• Benzaldehydes (chemistry, isolation & purification, pharmacology)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Diarylheptanoids (chemistry, isolation & purification, pharmacology)
• Drugs, Chinese Herbal (chemistry, isolation & purification, pharmacology)
• Flavonoids (chemistry, isolation & purification, pharmacology)
• Fruit (chemistry)
• Guaiacol (analogs & derivatives, chemistry, isolation & purification, pharmacology)
• HT29 Cells
• Humans