Abstract | BACKGROUND: METHODS AND RESULTS: Closed-chest transcatheter cryoablation was applied with 7F, 6-mm tip (n=11, 7F group) and 9F, 8-mm tip (n=8, 9F group) catheters to the left ventricular (LV) endocardium and epicardium. Catheter-tip temperature was set to -70 to -80 degrees C, and cryoablation duration was set to 240 s. In acute experiments in the 7F group, endocardial lesion volume was 144.1 +/-86.0 mm(3) and lesion depth was 5.1 +/-1.6 mm, and epicardial lesion volume was 205.6 +/-157.8 mm(3) and lesion depth was 4.7 +/-2.2 mm. In the 9F group, endocardial lesion volume was 301.5 +/-177.4 mm(3) (P<0.001 vs 7F group) and lesion depth was 8.4 +/-1.9 mm (P<0.001 vs 7F group), and epicardial lesion volume was 375.3 +/-167.6 mm(3) (P<0.01 vs 7F group) and lesion depth was 5.0 +/-2.3 mm. CONCLUSIONS: Transcatheter cryoablation of the LV endocardium and epicardium using a larger profile and longer tip electrode may be useful for treating VT originating from the midmyocardium or epicardium.
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Authors | Kenichi Hashimoto, Ichiro Watanabe, Yasuo Okumura, Kimie Ohkubo, Sonoko Ashino, Masayoshi Kofune, Toshiko Nakai, Satoshi Kunimoto, Yuji Kasamaki, Atsushi Hirayama |
Journal | Circulation journal : official journal of the Japanese Circulation Society
(Circ J)
Vol. 73
Issue 9
Pg. 1619-26
(Sep 2009)
ISSN: 1347-4820 [Electronic] Japan |
PMID | 19638710
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Animals
- Cardiac Catheterization
(adverse effects, instrumentation)
- Cryosurgery
(adverse effects, instrumentation)
- Dogs
- Endocardium
(pathology, surgery)
- Equipment Design
- Heart Ventricles
(pathology, surgery)
- Models, Animal
- Necrosis
- Pericardium
(pathology, surgery)
- Swine
- Time Factors
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