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Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats.

Abstract
We have investigated antihyperlipidaemic effect of swertiamarin (50 mg/kg, oral once) isolated from the perennial herb Enicostemma littorale Blume in poloxamer 407 (P-407)-induced hyperlipidaemic rats. Rats were made hyperlipidaemic by intraperitoneal administration of P-407 (400 mg/kg). Serum lipid levels such as total cholesterol, triglycerides and low-density lipoprotein cholesterol increased significantly (P < 0.001) compared with normal control rats. All these changes were significantly prevented in the rats treated with swertiamarin. Serum high-density lipoprotein (HDL) cholesterol was found to be reduced in the P-407 control rats. However, administration of swertiamarin significantly (P < 0.01) increased HDL levels and it showed a significant lipid-lowering effect, as well as a high antiatherogenic potential. Overall swertiamarin is an effective lipid-lowering lead compound and can be useful for preventing atherosclerosis.
AuthorsHitesh Vaidya, Mandapati Rajani, Vasudevan Sudarsanam, Harish Padh, Ramesh Goyal
JournalJournal of natural medicines (J Nat Med) Vol. 63 Issue 4 Pg. 437-42 (Oct 2009) ISSN: 1861-0293 [Electronic] Japan
PMID19633811 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Glucosides
  • Hypolipidemic Agents
  • Iridoid Glucosides
  • Iridoids
  • Pyrones
  • Poloxamer
  • swertiamarin
Topics
  • Animals
  • Glucosides (pharmacology)
  • Hyperlipidemias (chemically induced, drug therapy)
  • Hypolipidemic Agents (pharmacology)
  • Iridoid Glucosides
  • Iridoids (pharmacology)
  • Male
  • Poloxamer (pharmacology)
  • Pyrones (pharmacology)
  • Rats
  • Rats, Wistar

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