Long-term linezolid treatment in a young child with extensively drug-resistant tuberculosis.

Abstract

Treatment of extensively drug-resistant tuberculosis (XDR-TB) is a challenge. We describe a young child with pulmonary XDR-TB who did not respond to an aggressive multidrug-resistant TB treatment regimen, but was cured with linezolid in combination with other reserve antituberculous drugs. No serious adverse events were observed during 19 months of treatment for XDR-TB.

• Authors: H Simon Schaaf, Marianne Willemse, Peter R Donald
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 28 Issue 8 Pg. 748-50 (Aug 2009) ISSN: 0891-3668 [Print] United States
• PMID: 19633523 (Publication Type: Case Reports, Journal Article)

Chemical References

• Acetamides
• Antitubercular Agents
• Oxazolidinones
• Linezolid

Topics

• Acetamides (administration & dosage, adverse effects)
• Antitubercular Agents (administration & dosage)
• Drug Administration Schedule
• Drug Resistance, Multiple, Bacterial
• Extensively Drug-Resistant Tuberculosis (drug therapy, microbiology)
• Female
• Humans
• Infant
• Linezolid
• Oxazolidinones (administration & dosage, adverse effects)
• Tuberculosis, Pulmonary (drug therapy, microbiology)