Abstract | OBJECTIVES: METHODS: Six-week-old male spontaneously hypertensive rats (SHR) were treated with indapamide (1 mg/kg per day) or captopril (10 mg/kg per day) or a combination of indapamide plus captopril. After the 6-week treatment, nitric oxide synthase (NOS) activity, the expression of NOS isoform proteins, conjugated dienes concentration and relaxation responses of the femoral artery were analyzed. RESULTS: CONCLUSION: Whereas captopril reduced LVH, indapamide enhanced NOS activity and decreased oxidative damage in the case of the combined treatment. It is concluded that the complex protective effects of the combined indapamide plus captopril treatment on hypertension may be exerted via its effects on blood pressure, hypertrophy and vasorelaxation.
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Authors | Stanislava Vranková, Lydia Jendekova, Ludovit Paulis, Martina Sladkova, Fedor Simko, Olga Pechanova |
Journal | Journal of hypertension. Supplement : official journal of the International Society of Hypertension
(J Hypertens Suppl)
Vol. 27
Issue 6
Pg. S42-6
(Aug 2009)
ISSN: 1747-3667 [Electronic] England |
PMID | 19633451
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Captopril
- Nitric Oxide Synthase
- Indapamide
- Acetylcholine
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Topics |
- Acetylcholine
(metabolism)
- Animals
- Antihypertensive Agents
(pharmacology)
- Blood Pressure
- Captopril
(pharmacology)
- Femoral Artery
(pathology)
- Hypertension
(drug therapy)
- Hypertrophy, Left Ventricular
(pathology)
- Indapamide
(pharmacology)
- Kidney
(drug effects)
- Nitric Oxide Synthase
(metabolism)
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Treatment Outcome
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