Phenprocoumon-induced hepatitis mimicking non-A, non-B hepatitis.

Abstract

A 58-year-old man presented with jaundice 6 months after aortic valve replacement. Although non-A, non-B hepatitis was initially suspected, the final diagnosis of phenprocoumon (Marcoumar)-induced hepatitis progressing to cirrhosis was based on recurrence of jaundice after re-exposure to the drug, improvement after withdrawal and centrilobular necrosis with eosinophilic infiltration in the liver biopsy. Antibodies to hepatitis C virus were absent. The aortic valve was replaced by a bioprosthesis to eliminate the need for life-long anticoagulation.

• Authors: R A de Man, J H Wilson, S W Schalm, F J ten Kate, E van Leer
• Journal: Journal of hepatology (J Hepatol) Vol. 11 Issue 3 Pg. 318-21 (Nov 1990) ISSN: 0168-8278 [Print] Netherlands
• PMID: 1963177 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Viral
• Phenprocoumon

Topics

• Antibodies, Viral (analysis, immunology)
• Chemical and Drug Induced Liver Injury (diagnosis, immunology, pathology)
• Diagnosis, Differential
• Hepacivirus (immunology)
• Hepatitis C (diagnosis, immunology, pathology)
• Humans
• Liver (pathology)
• Male
• Middle Aged
• Phenprocoumon (adverse effects, therapeutic use)
• Thromboembolism (drug therapy)