Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects.

Abstract

BACKGROUND:

Epinastine is a topical ophthalmic antihistamine and a mast cell stabilizer indicated for treatment of symptoms associated with allergic conjunctivitis.

OBJECTIVE:

The objective of this review is to provide a comprehensive overview of the pharmacology, clinical efficacy, tolerability and safety of epinastine 0.05% ophthalmic solution.

METHODS:

Medline literature review from 1950 to 2008.

CONCLUSIONS:

Epinastine 0.05% ophthalmic solution was found to be a safe and effective medication for the relief of symptoms of allergic conjunctivitis. Epinastine demonstrates very low CNS and cardiac toxicity.

• Authors: Shilpi Pradhan, Kumar Abhishek, Francis Mah
• Journal: Expert opinion on drug metabolism & toxicology (Expert Opin Drug Metab Toxicol) Vol. 5 Issue 9 Pg. 1135-40 (Sep 2009) ISSN: 1744-7607 [Electronic] England
• PMID: 19630694 (Publication Type: Journal Article, Review)

Chemical References

• Dibenzazepines
• Histamine Antagonists
• Imidazoles
• epinastine

Topics

• Clinical Trials as Topic
• Conjunctivitis, Allergic (drug therapy)
• Dibenzazepines (administration & dosage, adverse effects, pharmacology, therapeutic use)
• Histamine Antagonists (administration & dosage, adverse effects, pharmacology, therapeutic use)
• Humans
• Imidazoles (administration & dosage, adverse effects, pharmacology, therapeutic use)