Abstract | OBJECTIVES: Although a positive resection margin has been reported to be a strong prognostic factor after resection for pancreatic cancer, several studies indicated that resection status did not independently affect survival. The aim of this study was to examine the influence of resection margin status on survival after extended radical resection for pancreatic head cancer. METHODS: RESULTS: The resection margins were negative (R0) in 115 patients (65.3%), microscopically positive (R1) in 38 patients (21.6%), and grossly positive (R2) in 23 patients (13.1%). Patients with R1 resection survived significantly shorter (median survival time [MST], 9.4 months) than R0 resection patients (MST, 15.2 months) but survived longer than R2 resection patients (MST, 6.2 months). By multivariate analysis, R2 resection, together with lymph node metastasis, portal venous system, and extrapancreatic nerve plexus invasions, independently affected the overall survival, but R1 resection was not significantly influential. CONCLUSIONS:
|
Authors | Koichi Kato, Suguru Yamada, Hiroyuki Sugimoto, Naohito Kanazumi, Shuji Nomoto, Shin Takeda, Yasuhiro Kodera, Satoshi Morita, Akimasa Nakao |
Journal | Pancreas
(Pancreas)
Vol. 38
Issue 6
Pg. 605-12
(Aug 2009)
ISSN: 1536-4828 [Electronic] United States |
PMID | 19629002
(Publication Type: Journal Article)
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Combined Modality Therapy
- Female
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Multivariate Analysis
- Neoplasm Staging
- Pancreatectomy
(methods)
- Pancreatic Neoplasms
(pathology, surgery, therapy)
- Pancreaticoduodenectomy
(methods)
- Prognosis
- Retrospective Studies
|