Coeliac sprue-associated membranoproliferative glomerulonephritis (MPGN).

Coeliac sprue (CS) may occur in association with immune complex-mediated diseases, including IgA nephropathy, dermatitis herpetiformis and thyroiditis. An association of CS with membranoproliferative glomerulonephritis (MPGN) type 1 is rare, with only two prior cases reported. Here we describe a 45-year-old man with no prior medical history who presented initially with microhaematuria, subnephrotic proteinuria and hypocomplementaemia. A renal biopsy revealed MPGN type 1 with negative serologic workup for secondary causes. The patient was treated conservatively with angiotensin-converting enzyme inhibitors. Several months later, he developed daily non-bloody diarrhoea and was found to have worsening hypoalbuminaemia, hypophosphataemia and severe iron deficiency anaemia. A diagnosis of CS was established based on elevated tTGA (IgA anti-tissue transglutaminase) antibody and positive IgA antiendomysial antibody titres. Proteinuria resolved completely following the initiation of a gluten-free diet, without the use of immunosuppressive therapy and despite tapering of angiotensin-converting enzyme inhibitor. This case illustrates that CS-associated MPGN may precede overt clinical evidence of coeliac disease and may respond to gluten-free diet, without resort to immunosuppressive therapy.
AuthorsKenar D Jhaveri, Vivette D D'Agati, Robert Pursell, David Serur
JournalNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (Nephrol Dial Transplant) Vol. 24 Issue 11 Pg. 3545-8 (Nov 2009) ISSN: 1460-2385 [Electronic] England
PMID19625370 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunoglobulin A
  • Celiac Disease (complications, immunology, therapy)
  • Glomerulonephritis, Membranoproliferative (etiology, pathology)
  • Humans
  • Immunoglobulin A (blood)
  • Kidney (pathology)
  • Male
  • Middle Aged

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