Abstract | BACKGROUND: METHODS: C57L/6 mice implanted with Lewis lung carcinoma were randomized into the control, ginsenoside Rg3, gemcitabine and combination group. The quality of life and survival of mice were recorded. Tumor volume, inhibitive rate and necrosis rate were estimated. Necrosis of tumor and signals of blood flow as well as dynamic parameters of arterial blood flow in tumors such as peak systolic velocity (PSV) and resistive index (RI) were detected by color Doppler ultrasound. In addition, expression of vascular endothelial cell growth factor ( VEGF) and CD31 were observed by immunohistochemstry, and microvessel density (MVD) of the tumor tissues was assessed by CD31 immunohistochemical analysis. RESULTS: Quality of life of mice in the ginsenoside Rg3 and combination group were better than in the control and gemcitabine group. Combined therapy with ginsenoside Rg3 and gemcitabine not only enhanced efficacy on suppression of tumor growth and prolongation of the survival, but also increased necrosis rate of tumor significantly. In addition, the combination treatment could obviously decrease VEGF expression and MVD as well as signals of blood flow and PSV in tumors. CONCLUSION:
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Authors | Tai-Guo Liu, Ying Huang, Dan-Dan Cui, Xiao-Bing Huang, Shu-Hua Mao, Ling-Ling Ji, Hai-Bo Song, Cheng Yi |
Journal | BMC cancer
(BMC Cancer)
Vol. 9
Pg. 250
(Jul 23 2009)
ISSN: 1471-2407 [Electronic] England |
PMID | 19624862
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ginsenosides
- Vascular Endothelial Growth Factor A
- Deoxycytidine
- ginsenoside Rg3
- Gemcitabine
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Topics |
- Animals
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, pharmacology)
- Carcinoma, Lewis Lung
(blood supply, drug therapy, pathology)
- Cell Growth Processes
(drug effects)
- Deoxycytidine
(administration & dosage, adverse effects, analogs & derivatives)
- Female
- Ginsenosides
(administration & dosage, adverse effects)
- Humans
- Lung Neoplasms
(blood supply, drug therapy, pathology)
- Mice
- Mice, Inbred BALB C
- Neovascularization, Pathologic
(drug therapy, pathology)
- Random Allocation
- Tumor Cells, Cultured
- Vascular Endothelial Growth Factor A
(biosynthesis)
- Gemcitabine
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