Efficacy of amoxicillin bearing microsphere formulation in treatment of Listeria monocytogenes infection in Swiss albino mice.

Abstract	The present study deals with the evaluation of the efficacy of amoxicillin bearing poly-lactic-glycolic acid (PLGA) microsphere formulation in treatment of experimental listeriosis in Swiss albino mice. Amoxicillin bearing PLGA microspheres were prepared by water-in-oil-in-water emulsion technique. PLGA microwspheres significantly regulated sustained release of encapsulated drug over extended time period. The rate of release increased in temperature dependent manner. Amoxicillin bearing PLGA microsphere successfully cleared bacterial burdens in vital organs (kidney, spleen, and brain) and also increased survival rate of treated animals in comparison to free form of the drug. The higher efficacy of microsphere based novel formulation of amoxicillin could be attributed to its targeted delivery to infected macrophages as well as sustained release over extended period of time.
Authors	Mohammad Farazuddin, Maroof Alam, Azmat Ali Khan, Nargis Khan, Shadab Parvez, Gupta Umesh Dutt, Owais Mohammad
Journal	Journal of drug targeting (J Drug Target) Vol. 18 Issue 1 Pg. 45-52 (Jan 2010) ISSN: 1029-2330 [Electronic] England
PMID	19624287 (Publication Type: Comparative Study, Journal Article)
Chemical References	Anti-Bacterial Agents Delayed-Action Preparations Drug Carriers Polylactic Acid-Polyglycolic Acid Copolymer Polyglycolic Acid Lactic Acid Amoxicillin
Topics	Amoxicillin (administration & dosage, pharmacology) Animals Anti-Bacterial Agents (administration & dosage, pharmacology) Chemistry, Pharmaceutical Delayed-Action Preparations Drug Carriers (chemistry) Drug Delivery Systems Female Lactic Acid (chemistry) Listeria monocytogenes (isolation & purification) Listeriosis (drug therapy, microbiology, mortality) Macrophages (metabolism) Mice Microspheres Polyglycolic Acid (chemistry) Polylactic Acid-Polyglycolic Acid Copolymer Survival Rate Temperature Time Factors

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