[Influence of effect of Suxiao Jiuxinwan on angiogenesis in experimental myocardial infarction rats].

Abstract

OBJECTIVE:

To study the effect of Suxiao Jiuxinwan on angiogenesis in experimental myocardial infarction rats.

METHOD:

The animal model was established by ligation of anterior decending coronary artery and the infarction areas as well as microvascular density (MVD) in the marginal infarction area of the myocardial infarction rats were observed.

RESULT:

Infarction areas in high dose and low dose Suxiao Jiuxinwan groups were significantly different from that of model group (P<0.01), and this effect was similar with the positive model group and had the dosage-dependent speciality. The microvascular density (MVD) of marginal infarction areas in Suxiao Jiuxinwan high and low groups was much more elevated than that in the sham group (P<0.05), and the effect of Suxiao Jiuxinwan high group was similar with that of the positive control group. But the difference between the Suxiao Jiuxinwan high and the low goups was not significant.

CONCLUSION:

Suxiao Jiuxinwan has the obvious effcet on angiogenesis in eperimental myocardial infarction rats.

• Authors: Ling Feng, Jie Wang, Shuanghou Cheng, Riuhua Liu, Fuyong Chu
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 34 Issue 6 Pg. 748-50 (Mar 2009) ISSN: 1001-5302 [Print] China
• PMID: 19624021 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drugs, Chinese Herbal
• suxiao jiuxinwan

Topics

• Animals
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Male
• Microvessels (drug effects, physiopathology)
• Myocardial Infarction (drug therapy, physiopathology)
• Neovascularization, Pathologic (drug therapy)
• Rats