Cancer chemopreventive activity of oleanane-type triterpenoids from the stem bark of Betula ermanii.

Abstract

In search for cancer chemopreventive agents from natural sources, three oleanane- and four known lupane-type triterpenoids, and sitosterol from the stem bark of Betula ermanii were tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Among them, 3beta-acetoxy-12alpha-hydroxyoleanan-13beta,28-olide (1) and 3beta-acetoxy-11alpha,12alpha-epoxyoleanan-13beta,28-olide (2) were investigated for the inhibitory effect in a two-stage carcinogenesis test on mouse skin using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter. 3beta-Acetoxy-11alpha,12alpha-epoxyoleanan-13beta,28-olide (2) was found to exhibit the potent antitumor promoting activity in the in vivo carcinogenesis test.

• Authors: Chiharu Yamaguchi, Yasuko In, Shun-ichi Wada, Takeshi Yamada, Harukuni Tokuda, Reiko Tanaka
• Journal: Chemistry & biodiversity (Chem Biodivers) Vol. 6 Issue 7 Pg. 1093-100 (Jul 2009) ISSN: 1612-1880 [Electronic] Switzerland
• PMID: 19623559 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Antigens, Viral
• Epstein-Barr virus early antigen
• Triterpenes
• oleanane
• Oleanolic Acid
• Tetradecanoylphorbol Acetate

Topics

• Animals
• Anticarcinogenic Agents (chemistry, isolation & purification, pharmacology)
• Antigens, Viral (drug effects, metabolism)
• Betula (chemistry)
• Carcinogenicity Tests
• Female
• Mice
• Mice, Inbred ICR
• Oleanolic Acid (analogs & derivatives, chemistry)
• Papilloma (chemically induced, prevention & control)
• Plant Bark (chemistry)
• Plant Stems (chemistry)
• Skin Neoplasms (chemically induced, prevention & control)
• Tetradecanoylphorbol Acetate (pharmacology)
• Triterpenes (chemistry, isolation & purification, pharmacology)