Abstract | OBJECTIVE: METHODS: Diffusion-weighted magnetic resonance imaging and positron emission tomography were performed before surgery in 110 patients with 124 pulmonary nodules smaller than 3 cm, including 96 non-small cell lung cancers and 28 benign nodules. Diffusion of water molecules in magnetic resonance imaging was measured by minimum value of apparent diffusion coefficient. The criterion standard was the result of histologic diagnosis or follow-up examination. Sensitivity and specificity for differentiating between cancers and benign nodules were compared between diffusion-weighted imaging and positron emission tomography. Apparent diffusion coefficient in diffusion-weighted imaging and fludeoxyglucose F 18 uptake in positron emission tomography were examined with respect to pathologic tumor stage; lymphatic, vascular and pleural involvements; and histologic differentiation. RESULTS: There were no significant differences between diffusion-weighted magnetic resonance imaging and positron emission tomography in sensitivity or specificity for non-small cell lung cancer. Whereas positron emission tomography showed significant differences in fludeoxyglucose F 18 uptake between pathologic stages IA versus IB or more advanced stages; between tumors with and without lymphatic, vascular, or pleural involvement; and between well-differentiated and moderately or poorly differentiated adenocarcinomas (P <.01-0.001), no significant differences in apparent diffusion coefficient values in were observed. CONCLUSION:
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Authors | Yasuomi Ohba, Hiroaki Nomori, Takeshi Mori, Koei Ikeda, Hidekatsu Shibata, Hironori Kobayashi, Shinya Shiraishi, Kazuhiro Katahira |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 138
Issue 2
Pg. 439-45
(Aug 2009)
ISSN: 1097-685X [Electronic] United States |
PMID | 19619793
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Non-Small-Cell Lung
(diagnosis, diagnostic imaging)
- Diffusion Magnetic Resonance Imaging
- Female
- Fluorodeoxyglucose F18
- Humans
- Lung Neoplasms
(diagnosis, diagnostic imaging)
- Male
- Middle Aged
- Positron-Emission Tomography
- Radiopharmaceuticals
- Sensitivity and Specificity
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