Abstract |
Particle radiations using protons or carbons, and boron neutron capture therapy are emerging as a therapeutic modality for malignant gliomas. Some non-randomized prospective studies found favorable results; however, the advantageous method of advantage of conformal radiation using protons or carbon ions and tumor cell-selective radiation using boron neutron capture therapy have not been confirmed. In a recent clinical trial involving 20 newly diagnosed glioblastomas at the Proton Medical Research Center at Tsukuba, the median overall survival time and the 1- and 2-year survival rates were 21.6 months, 71.1% and 45.3%, respectively. In the clinical trial of boron neutron capture therapy of 15 newly diagnosed glioblastomas at Tsukuba, the median overall survival time and the 1- and 2-year survival rates were 25.7 month, 80.0% and 53.3%, respectively. The rationale, history, and clinical results of particle radiotherapy for glioblastoma were also discussed.
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Authors | Tetsuya Yamamoto, Koji Tsuboi |
Journal | Brain and nerve = Shinkei kenkyu no shinpo
(Brain Nerve)
Vol. 61
Issue 7
Pg. 855-66
(Jul 2009)
ISSN: 1881-6096 [Print] Japan |
PMID | 19618864
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
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Topics |
- Boron Neutron Capture Therapy
- Brain Neoplasms
(radiotherapy)
- Carbon Radioisotopes
(therapeutic use)
- Clinical Trials as Topic
- Glioma
(radiotherapy)
- Humans
- Neutron Capture Therapy
(instrumentation, trends)
- Proton Therapy
- Treatment Outcome
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