Study on the potential anti-cancer activity of phosphonium and ammonium-based ionic liquids.

Abstract

The anti-cancer activity and cytotoxicity of phosphonium and ammonium-based ionic liquids (ILs) have been determined for the first time via NCI's in vitro 60 human tumor cell lines. The preliminary SAR showed that the chain length of alkyl substitution on the cations plays crucial role towards anti-tumor activity and cytotoxicity of these ionic liquids. In general, phosphonium-based ILs were found to be more active and less cytotoxic as compared to ammonium ILs. Cell line data and hollow fiber study has demonstrated the potential of ILs to be developed as therapeutic agent.

• Authors: Vineet Kumar, Sanjay V Malhotra
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 19 Issue 16 Pg. 4643-6 (Aug 15 2009) ISSN: 1464-3405 [Electronic] England
• PMID: 19615902 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Antineoplastic Agents
• Ionic Liquids
• Organophosphorus Compounds
• Quaternary Ammonium Compounds

Topics

• Antineoplastic Agents (chemistry, pharmacology, toxicity)
• Cell Line, Tumor
• Drug Screening Assays, Antitumor
• Humans
• Ionic Liquids (chemistry, pharmacology, toxicity)
• Organophosphorus Compounds (chemistry, pharmacology, toxicity)
• Quaternary Ammonium Compounds (chemistry, pharmacology, toxicity)
• Structure-Activity Relationship