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Emerging roles of peroxisome proliferator-activated receptor-beta/delta in inflammation.

Abstract
Peroxisome proliferator-activated receptor (PPAR)-beta/delta is a member of the PPAR nuclear hormone receptor family. The PPARs are a family of 3 ligand-activated transcription factors: PPARalpha (NR1C1), PPARbeta/delta (NR1C2), and PPARgamma (NR1C3). All the PPARs play important roles in the regulation of metabolic pathways, including those of lipid of biosynthesis and glucose metabolism, as well as in a variety of cell differentiation, proliferation, and apoptosis pathways. Recently, there has been a great deal of interest in the involvement of PPARs in the inflammatory processes. In particular, PPARalpha and PPARgamma inhibit the activation of inflammatory gene expression and can negatively interfere with pro-inflammatory transcription factor signalling pathways in vascular and inflammatory cells. In contrast, the roles of PPARbeta/delta regulating inflammation and immunity are only just emerging. This review will focus on these emerging roles of PPARbeta/delta in regulating inflammatory processes.
AuthorsDavid Bishop-Bailey, Jonas Bystrom
JournalPharmacology & therapeutics (Pharmacol Ther) Vol. 124 Issue 2 Pg. 141-50 (Nov 2009) ISSN: 1879-016X [Electronic] England
PMID19615407 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Inflammation Mediators
  • Ligands
  • PPAR delta
  • PPAR-beta
Topics
  • Animals
  • Humans
  • Inflammation (genetics, metabolism)
  • Inflammation Mediators (metabolism, physiology)
  • Ligands
  • PPAR delta (metabolism, physiology)
  • PPAR-beta (metabolism, physiology)
  • Signal Transduction (physiology)

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