Abstract | BACKGROUND: Perineural invasion (PNI) is a well-recognized route of tumor extension in cutaneous neoplasms. Despite an established association with increased local recurrences and metastases, the mechanisms responsible for PNI have yet to be elucidated. We hypothesize that P75 NGFR, a nerve growth factor receptor, may be implicated in the pathogenesis of PNI in these tumors. METHODS: RESULTS: P75 NGFR staining was absent in all invasive SCCs irrespective of the presence of PNI (n = 0/36). Two BCCs with PNI (n = 2/8) and three without PNI (n = 3/7) showed focal P75 NGFR staining. Interestingly, 8 of 10 invasive MMs with PNI had positive P75 NGFR expression (80%), in contrast to only 1 of 9 without PNI (11%). CONCLUSIONS: P75 NGFR may play a mechanistic role in invasive MMs demonstrating PNI. Furthermore, its expression may serve as a marker of PNI in those tumors that lack histological evidence of nerve involvement at the time of excision.
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Authors | Maren M Chan, Steven R Tahan |
Journal | Journal of cutaneous pathology
(J Cutan Pathol)
Vol. 37
Issue 3
Pg. 336-43
(Mar 2010)
ISSN: 1600-0560 [Electronic] United States |
PMID | 19615036
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Receptor, Nerve Growth Factor
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Topics |
- Biomarkers, Tumor
- Carcinoma, Basal Cell
(metabolism, pathology)
- Carcinoma, Squamous Cell
(metabolism, pathology)
- Humans
- Immunohistochemistry
- Melanoma
(metabolism, pathology)
- Neoplasm Invasiveness
(pathology)
- Receptor, Nerve Growth Factor
(metabolism)
- Skin
(innervation, metabolism, pathology)
- Skin Neoplasms
(metabolism, pathology)
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