Abstract | INTRODUCTION: PATIENTS AND METHODS: Children with atopic dermatitis were randomized into 2 groups treated for 2 weeks. One group of children (n = 60) was treated with a basic emollient cream and the other (n = 57) was treated with the same cream enriched with furfuryl palmitate. RESULTS: In both groups, there was a significant reduction (P < .001) in atopic dermatitis-measured using the SCORAD index-after 14 days. The reduction in the per-protocol analysis was higher for the basic cream. Treatment success was defined as a reduction of 20% or more in the SCORAD index from baseline to day 14. Patients who used treatment not permitted by the protocol were also considered treatment failures. The intention-to-treat analysis showed 70% positive results for the basic treatment and 29% for the treatment containing furfuryl palmitate (P < .0001) with a number needed to treat of 2.4 (95% confidence interval, 1.6-4.6). The emollient cream without furfuryl palmitate was observed to be more efficacious by pediatricians and parents, and no differences were reported between the 2 products in terms of tolerability. CONCLUSIONS:
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Authors | S Tripodi, A Di Rienzo Businco, V Panetta, G Pingitore, A Volterrani, T Frediani, S Pelosi, S Miceli Sopo |
Journal | Journal of investigational allergology & clinical immunology
(J Investig Allergol Clin Immunol)
Vol. 19
Issue 3
Pg. 204-9
( 2009)
ISSN: 1018-9068 [Print] Spain |
PMID | 19610263
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Emollients
- Furans
- Palmitates
- furfuryl palmitate
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Topics |
- Administration, Cutaneous
- Child
- Child, Preschool
- Dermatitis, Atopic
(drug therapy)
- Double-Blind Method
- Emollients
(administration & dosage)
- Female
- Furans
(administration & dosage)
- Humans
- Infant
- Male
- Palmitates
(administration & dosage)
- Treatment Outcome
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