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Lack of efficacy of topical furfuryl palmitate in pediatric atopic dermatitis: a randomized double-blind study.

AbstractINTRODUCTION:
Atopic dermatitis is a common disease in children. It is usually treated with topical steroids and/or calcineurin inhibitors in association with emollients but topical antioxidants have been recently introduced as a therapeutic option for children. The aim of this study was to evaluate the efficacy and tolerability of furfuryl palmitate, a new antioxidant molecule, in a multicenter, randomized, double-blind, vehicle-controlled study.
PATIENTS AND METHODS:
Children with atopic dermatitis were randomized into 2 groups treated for 2 weeks. One group of children (n = 60) was treated with a basic emollient cream and the other (n = 57) was treated with the same cream enriched with furfuryl palmitate.
RESULTS:
In both groups, there was a significant reduction (P < .001) in atopic dermatitis-measured using the SCORAD index-after 14 days. The reduction in the per-protocol analysis was higher for the basic cream. Treatment success was defined as a reduction of 20% or more in the SCORAD index from baseline to day 14. Patients who used treatment not permitted by the protocol were also considered treatment failures. The intention-to-treat analysis showed 70% positive results for the basic treatment and 29% for the treatment containing furfuryl palmitate (P < .0001) with a number needed to treat of 2.4 (95% confidence interval, 1.6-4.6). The emollient cream without furfuryl palmitate was observed to be more efficacious by pediatricians and parents, and no differences were reported between the 2 products in terms of tolerability.
CONCLUSIONS:
Both products proved to be efficacious in treating atopic dermatitis in children, but the emollient cream not containing furfuryl palmitate showed better clinical efficacy.
AuthorsS Tripodi, A Di Rienzo Businco, V Panetta, G Pingitore, A Volterrani, T Frediani, S Pelosi, S Miceli Sopo
JournalJournal of investigational allergology & clinical immunology (J Investig Allergol Clin Immunol) Vol. 19 Issue 3 Pg. 204-9 ( 2009) ISSN: 1018-9068 [Print] Spain
PMID19610263 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Emollients
  • Furans
  • Palmitates
  • furfuryl palmitate
Topics
  • Administration, Cutaneous
  • Child
  • Child, Preschool
  • Dermatitis, Atopic (drug therapy)
  • Double-Blind Method
  • Emollients (administration & dosage)
  • Female
  • Furans (administration & dosage)
  • Humans
  • Infant
  • Male
  • Palmitates (administration & dosage)
  • Treatment Outcome

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