[In vitro antifungal activities of amorolfine against fresh isolates from patients with cutaneous mycosis].

Abstract

In vitro antifungal activities of amorolfine (MT-861), a new morpholine antifungal agent, were examined using an agar-dilution method, in comparison with those of 2 other antifungal agents, clotrimazole (CTZ) and bifonazole (BFZ), against 182 clinical isolates of Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis, and Epidermophyton floccosum, which had been freshly isolated from a total of 182 cutaneous mycotic patients with various types of dermatophytes or cutaneous candidiasis. Antifungal activities of the 3 drugs against T. rubrum were in the order of MT-861 greater than CTZ greater than BFZ, with the lowest average MIC values (0.0070 micrograms/ml) obtained with MT-861. The average MIC value of MT-861 for clinical isolates from patients with pedis was roughly 2.3-fold higher than that for those from patients with tinea corporis. Out of 3 drugs tested MT-861 exhibited the most potent activities against clinical isolates of T. mentagrophytes, M. canis, and E. floccosum with average MIC values of 0.0267, 0.0079, and 0.0018 micrograms/ml, respectively. MIC values of MT-861 against isolates of Candida albicans ranged from 0.01 to 10 micrograms/ml, and the average value (0.1762 micrograms/ml) was the lowest of the 3 drugs.

• Authors: K Uchida, K Aoki, H Yamaguchi
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 44 Issue 9 Pg. 1007-12 (Sep 1991) ISSN: 0368-2781 [Print] Japan
• PMID: 1960850 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antifungal Agents
• Imidazoles
• Morpholines
• amorolfine
• Clotrimazole
• bifonazole

Topics

• Antifungal Agents (pharmacology)
• Clotrimazole (pharmacology)
• Dermatomycoses (microbiology)
• Fungi (drug effects, isolation & purification)
• Humans
• Imidazoles (pharmacology)
• Microbial Sensitivity Tests
• Morpholines (pharmacology)