Osteogenic biphasic calcium sulphate dihydrate/iron-modified alpha-tricalcium phosphate bone cement for spinal applications: in vivo study.

Abstract

In this study, the biocompatibility and the osteogenic features of a new iron-modified alpha-tricalcium phosphate (IM/alpha-TCP) and calcium sulphate dihydrate (CSD) biphasic cement (IM/alpha-TCP/CSD-BC) have been investigated in terms of the in vivo cement resorption, bone tissue formation and host tissue response on sheep animal model. Histological evaluation performed on undecalcified cement-bone specimens assessed the in vivo behaviour. It has been shown that the new IM/alpha-TCP/CSD-BC has the ability to produce firm bone binding in vivo (i.e. bioactivity). Qualitative histology proved cement biocompatibility, osteoconduction and favourable resorption, mainly through a macrophage-mediated mechanism. The results showed that the new cements have biocompatible and osteogenic features of interest as possible cancellous bone replacement biomaterial for minimally invasive spinal surgery applications.

• Authors: M D Vlad, E V Sindilar, M L Mariñoso, I Poeată, R Torres, J López, M Barracó, E Fernández
• Journal: Acta biomaterialia (Acta Biomater) Vol. 6 Issue 2 Pg. 607-16 (Feb 2010) ISSN: 1878-7568 [Electronic] England
• PMID: 19607944 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biocompatible Materials
• Bone Cements
• Calcium Phosphates
• Iron
• tricalcium phosphate
• Calcium Sulfate

Topics

• Animals
• Biocompatible Materials
• Bone Cements
• Calcium Phosphates (administration & dosage, chemistry)
• Calcium Sulfate (administration & dosage)
• Female
• Iron (chemistry)
• Sheep
• Spine (surgery)