[Rabbit osteosarcoma induced by hydroxypropylcellulose mixed beryllium oxide pellet--comparison between implantations into bone marrow cavity and into fracture callus of the femur].

Abstract

Hydroxypropylcellulose mixed beryllium oxide pellets were implanted into the distal metaphysis in the right femurs of 30 rabbits (3 groups, 10 rabbits each): in Group 1 into the internal callus 1 week after production of artificial fracture at a dose of 300 mg, in Group 2 into the bone marrow cavity at a dose of 300 mg, and in Group 3 into the bone marrow cavity at a dose of 50 mg. Osteosarcoma was induced in all of 10 rabbits in Group 1, 7 out of 10 in Group 2, 1 out of 10 in Group 3 at 56 weeks after implantation of BeO. In Group 1, the emergence of tumor and the increase of serum alkaline phosphatase appeared significantly earlier and 80% of the animals with osteosarcoma showed lung metastasis. This experimental method, especially that used in group 1, appears to be useful for the study of human osteosarcoma.

• Authors: T Hiruma
• Journal: Nihon Seikeigeka Gakkai zasshi (Nihon Seikeigeka Gakkai Zasshi) Vol. 65 Issue 9 Pg. 775-86 (Sep 1991) ISSN: 0021-5325 [Print] Japan
• PMID: 1960478 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Drug Implants
• beryllium oxide
• Cellulose
• hydroxypropylcellulose
• Alkaline Phosphatase
• Beryllium

Topics

• Alkaline Phosphatase (blood)
• Animals
• Beryllium
• Biomarkers, Tumor (blood)
• Bone Marrow
• Bone Neoplasms (chemically induced, pathology)
• Bony Callus (pathology)
• Cellulose (analogs & derivatives)
• Disease Models, Animal
• Drug Implants
• Femoral Fractures (pathology)
• Femur
• Lung Neoplasms (chemically induced, secondary)
• Male
• Osteosarcoma (chemically induced, pathology, secondary)
• Rabbits