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Expression of ezrin is associated with invasion and dedifferentiation of hepatitis B related hepatocellular carcinoma.

AbstractBACKGROUND:
Hepatocellular carcinoma (HCC) is the fifth most common malignancy in the world and constitutes the leading cause of cancer-related death among men, and second among women in Taiwan. Liver cirrhosis and HCC are relatively prevalent, and 80% to 85% of the patients with these conditions have positive results for hepatitis B surface antigen in Taiwan. Only 5% of the general population is seronegative for all hepatititis B virus (HBV) markers. This is the first study to determine the role of ezrin upon HBV HCC cell and patients with HBV HCC undergoing hepatectomy
METHODS:
Immunohistochemical study with ezrin in 104 human HBV-HCC cases were carried out to investigate its association with the clinicopathological features and the outcomes of 104 HBV-HCC patients undergoing hepatetomy. In addition, DNA constructs including the wild type ezrin (wt-ezrin) and mutant ezrin Tyr353 (Y353) were transfected into Hep3B cell to study its role in tumor invasion and differentiation.
RESULTS:
HBV HCC patients with ezrin over-expression independently have smaller tumor size, cirrhotic liver background, poor tumor differentiation, and more vascular invasion. Ezrin expression status has no impact on survival for HBV-HCC patients undergoing hepatectomy. The in vitro assay showed that wt-ezrin Hep3B cells have a significant higher level of AFP secretion and higher invasion ability as compared with the control and Y353- ezrin Hep3B cells.
CONCLUSION:
Ezrin over-expression contributed to de-differentiation and invasion of HBV-HCC cell. HBV-HCC patients with ezrin over-expression were independently associated with tumor with smaller size, cirrhotic liver background, poor differentiation, and vascular invasion.
AuthorsChun-Nan Yeh, See-Tong Pang, Tsung-Wen Chen, Ren-Ching Wu, Wen-Hui Weng, Miin-Fu Chen
JournalBMC cancer (BMC Cancer) Vol. 9 Pg. 233 (Jul 15 2009) ISSN: 1471-2407 [Electronic] England
PMID19604375 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cytoskeletal Proteins
  • ezrin
Topics
  • Adult
  • Aged
  • Carcinoma, Hepatocellular (complications, metabolism)
  • Cell Differentiation
  • Cytoskeletal Proteins (biosynthesis)
  • Female
  • Gene Expression Regulation, Neoplastic
  • Gene Expression Regulation, Viral
  • Hepatectomy
  • Hepatitis B (complications, metabolism)
  • Humans
  • Liver Neoplasms (complications, metabolism)
  • Male
  • Middle Aged
  • Mutation
  • Neoplasm Invasiveness
  • Treatment Outcome

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