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Metabolic effects of diphosphonate in primary hyperparathyroidism.

Abstract
Six patients with primary hyperparathyroidism (PHPT) and one with squamous cell carcinoma of the esophagus with parathyroid hormone excess received disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) at a daily dose of 20 mg/kg orally. During treatment, the decrease in urinary calcium, total urinary hydroxyproline, and fasting urinary calcium suggested an inhibition of bone resorption. Serum calcium intestinal absorption of calcium and urinary cyclic adenosine monophosphate (cAMP) did not change significantly. This preliminary study indicates a possible role of diphosphonates in the management of inoperable cases of primary hyperparathyroidism or pseudohyperparathyroidism.
AuthorsR A Kaplan, W B Geho, C Poindexter, M Haussler, G W Dietz, C Y Pak
JournalJournal of clinical pharmacology (J Clin Pharmacol) Vol. 17 Issue 7 Pg. 410-9 (Jul 1977) ISSN: 0091-2700 [Print] England
PMID195983 (Publication Type: Clinical Trial, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Dihydroxycholecalciferols
  • Parathyroid Hormone
  • Phosphates
  • Cyclic AMP
  • Alkaline Phosphatase
  • Etidronic Acid
  • Hydroxyproline
  • Calcium
Topics
  • Adult
  • Aged
  • Alkaline Phosphatase (blood)
  • Bone and Bones (metabolism)
  • Calcium (metabolism)
  • Clinical Trials as Topic
  • Cyclic AMP (urine)
  • Dihydroxycholecalciferols (blood)
  • Etidronic Acid (adverse effects, pharmacology, therapeutic use)
  • Female
  • Humans
  • Hydroxyproline (urine)
  • Hyperparathyroidism (drug therapy, metabolism, physiopathology)
  • Male
  • Middle Aged
  • Parathyroid Glands (physiopathology)
  • Parathyroid Hormone (blood)
  • Phosphates (blood)
  • Time Factors

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